Ephrin A1 Antikörper (AA 18-182) (HRP)

Produktnummer ABIN7178844

Produktdetails anti-Ephrin A1 Antikörper (HRP)

Target: Ephrin A1 (EFNA1)

Bindungsspezifität: AA 18-182

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Ephrin A1 Antikörper ist konjugiert mit HRP

Applikation: ELISA

Kreuzreaktivität: Ratte

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Rat Ephrin-A1 protein (18-182AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu Ephrin A1

Target: Ephrin A1 (EFNA1)

Andere Bezeichnung: Efna1 (EFNA1 Produkte)

Hintergrund:

Background: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis By similarity.

Aliases: Efna1 antibody, Epgl1 antibody, Lerk1 antibody, Ephrin-A1 antibody, EPH-related receptor tyrosine kinase ligand 1 antibody, LERK-1 antibody, Immediate early response protein B61) [Cleaved into: Ephrin-A1 antibody, secreted form] antibody

UniProt: P97553

Pathways: RTK Signalweg