Ephrin A5 Antikörper (AA 21-203) (Biotin)

Produktnummer ABIN7178846

Produktdetails anti-Ephrin A5 Antikörper (Biotin)

Target: Ephrin A5 (EFNA5)

Bindungsspezifität: AA 21-203

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Ephrin A5 Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Kreuzreaktivität: Ratte

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Rat Ephrin-A5 protein (21-203AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu Ephrin A5

Target: Ephrin A5 (EFNA5)

Andere Bezeichnung: Efna5 (EFNA5 Produkte)

Synonyme: EFNA5 antikoerper, af1 antikoerper, efl5 antikoerper, rags antikoerper, eplg7 antikoerper, lerk7 antikoerper, AL-1 antikoerper, AV158822 antikoerper, EFL-5 antikoerper, Ephrin-A5 antikoerper, Epl7 antikoerper, LERK-7 antikoerper, RAGS antikoerper, Lerk7 antikoerper, AF1 antikoerper, EFL5 antikoerper, EPLG7 antikoerper, GLC1M antikoerper, LERK7 antikoerper, ephrin A5 antikoerper, EFNA5 antikoerper, efna5 antikoerper, Efna5 antikoerper

Hintergrund:

Background: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the EPHA3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor EPHA2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fasciculation. The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell-cell adhesion and repulsion

Aliases: Efna5 antibody, Eplg7 antibody, Lerk7 antibody, Ephrin-A5 antibody, AL-1 antibody, EPH-related receptor tyrosine kinase ligand 7 antibody, LERK-7 antibody

UniProt: P97605

Pathways: RTK Signalweg