DDR1 Antikörper (Tyr796)

Produktnummer ABIN7180003

Produktdetails anti-DDR1 Antikörper

Target: DDR1 (Discoidin Domain Receptor tyrosine Kinase 1 (DDR1))

Bindungsspezifität: Tyr796

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DDR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized non-phosphopeptide derived from Human DDR1 around the phosphorylation site of tyrosine 796.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB:1:500-1:3000,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu DDR1

Target: DDR1 (Discoidin Domain Receptor tyrosine Kinase 1 (DDR1))

Andere Bezeichnung: DDR1 (DDR1 Produkte)

Synonyme: CG11573 antikoerper, CG13984 antikoerper, CG13985 antikoerper, CG33531 antikoerper, CG9488 antikoerper, CG9490 antikoerper, CT33540 antikoerper, DDR antikoerper, Dmel\\CG33531 antikoerper, Dmel_CG13984 antikoerper, 6030432F18 antikoerper, AI323681 antikoerper, CD167a antikoerper, Cak antikoerper, Nep antikoerper, PTK3A antikoerper, CAK antikoerper, CD167 antikoerper, EDDR1 antikoerper, HGK2 antikoerper, MCK10 antikoerper, NEP antikoerper, NTRK4 antikoerper, PTK3 antikoerper, RTK6 antikoerper, TRKE antikoerper, Drd1 antikoerper, PTK3D antikoerper, Discoidin domain receptor antikoerper, discoidin domain receptor family, member 1 antikoerper, discoidin domain receptor tyrosine kinase 1 antikoerper, Ddr antikoerper, Ddr1 antikoerper, DDR1 antikoerper

Hintergrund:

Background: Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing By similarity. Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11.

di Marco E., J. Biol. Chem. 268:24290-24295(1993).
Johnson J.D., Proc. Natl. Acad. Sci. U.S.A. 90:5677-5681(1993).

Aliases: CAK antibody, CD 167 antibody, CD167 antibody, CD167 antigen-like family member A antibody, CD167a antibody, Cell adhesion kinase antibody, DDR 1 antibody, DDR antibody, DDR1 antibody, DDR1_HUMAN antibody, Discoidin domain receptor antibody, Discoidin domain receptor tyrosine kinase 1 antibody, Discoidin receptor tyrosine kinase antibody, Discoidin receptor tyrosine kinase isoform a antibody, EDDR 1 antibody, EDDR1 antibody, Epithelial discoidin domain receptor 1 antibody, Epithelial discoidin domain-containing receptor 1 antibody, Epithelial specific receptor kinase antibody, HGK2 antibody, Mammarian carcinoma kinase 10 antibody, Mammary carcinoma kinase 10 antibody, MCK-10 antibody, MCK10 antibody, NEP antibody, Neuroepithelial tyrosine kinase antibody, Neurotrophic tyrosine kinase receptor type 4 antibody, NTRK 4 antibody, NTRK4 antibody, OTTHUMP00000029343 antibody, OTTHUMP00000029344 antibody, OTTHUMP00000029345 antibody, OTTHUMP00000029346 antibody, OTTHUMP00000029347 antibody, OTTHUMP00000164863 antibody, OTTHUMP00000164867 antibody, OTTHUMP00000222080 antibody, Protein-tyrosine kinase 3A antibody, Protein-tyrosine kinase RTK-6 antibody, PTK 3 antibody, PTK 3A protein tyrosine kinase 3A antibody, PTK3 antibody, PTK3A antibody, Receptor tyrosine kinase NEP antibody, RTK 6 antibody, RTK6 antibody, TRK E antibody, TRKE antibody, Tyrosine kinase DDR antibody, Tyrosine kinase receptor E antibody, Tyrosine-protein kinase CAK antibody

UniProt: Q08345

Pathways: RTK Signalweg, Smooth Muscle Cell Migration