MEF2C Antikörper (Ser396)

Produktnummer ABIN7180046

Produktdetails anti-MEF2C Antikörper

Target: MEF2C (Myocyte Enhancer Factor 2C (MEF2C))

Bindungsspezifität: Ser396

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MEF2C Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Kreuzreaktivität: Human, Maus

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized non-phosphopeptide derived from Human MEF2C around the phosphorylation site of serine 396 (P-V-S(p)-P-P).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB:1:500-1:3000,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu MEF2C

Target: MEF2C (Myocyte Enhancer Factor 2C (MEF2C))

Andere Bezeichnung: MEF2C (MEF2C Produkte)

Synonyme: MEF2C antikoerper, XMEF2C antikoerper, si:ch211-202e12.2 antikoerper, C5DELq14.3 antikoerper, DEL5q14.3 antikoerper, 5430401D19Rik antikoerper, 9930028G15Rik antikoerper, AV011172 antikoerper, Mef2 antikoerper, RGD1563119 antikoerper, id:ibd5026 antikoerper, mef2c antikoerper, wu:fc05b06 antikoerper, zgc:64184 antikoerper, zgc:85726 antikoerper, myocyte enhancer factor 2C antikoerper, MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C) antikoerper, myocyte enhancer factor 2cb antikoerper, MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C) L homeolog antikoerper, myocyte enhancer factor 2ca antikoerper, MEF2C antikoerper, mef2c antikoerper, mef2cb antikoerper, mef2c.L antikoerper, Mef2c antikoerper, mef2ca antikoerper

Hintergrund:

Background: Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture By similarity. Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2.

Leifer D., Proc. Natl. Acad. Sci. U.S.A. 90:1546-1550(1993).
McDermott J.C., Mol. Cell. Biol. 13:2564-2577(1993).
Wang A.H., Mol. Cell. Biol. 19:7816-7827(1999).

Aliases: C5DELq14.3 antibody, DEL5q14.3 antibody, MADS box transcription enhancer factor 2 polypeptide C (myocyte enhancer factor 2C) antibody, MADS box transcription enhancer factor 2, polypeptide C antibody, MEF2C antibody, MEF2C_HUMAN antibody, Myocyte enhancer factor 2C antibody, Myocyte specific enhancer factor 2C antibody, Myocyte-specific enhancer factor 2C antibody, OTTHUMP00000222409 antibody, Similar to MADS box transcription enhancer factor 2 polypeptide C antibody

UniProt: Q06413

Pathways: Neurotrophin Signalübertragung, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Chromatin Binding, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Toll-Like Receptors Cascades, BCR Signaling