PAK3 Antikörper (Ser154)

Produktnummer ABIN7180068

Produktdetails anti-PAK3 Antikörper

Target: PAK3

Bindungsspezifität: Ser154

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PAK3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Kreuzreaktivität: Human, Maus

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized non-phosphopeptide derived from Human PAK3 around the phosphorylation site of serine 154 (Y-M-S(p)-F-T).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB:1:500-1:3000,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu PAK3

Target: PAK3

Andere Bezeichnung: PAK3 (PAK3 Produkte)

Synonyme: CDKN1A antikoerper, MRX30 antikoerper, MRX47 antikoerper, OPHN3 antikoerper, PAK3beta antikoerper, bPAK antikoerper, hPAK3 antikoerper, PAK-3 antikoerper, Pak65alpha antikoerper, Pak65beta antikoerper, Stk4 antikoerper, beta-PAK antikoerper, XPak3 antikoerper, bpak antikoerper, cdkn1a antikoerper, mrx30 antikoerper, mrx47 antikoerper, ophn3 antikoerper, pak3 antikoerper, pak3-A antikoerper, pak3beta antikoerper, p21 (RAC1) activated kinase 3 antikoerper, p21 protein (Cdc42/Rac)-activated kinase 3 antikoerper, p21 protein (Cdc42/Rac)-activated kinase 3 L homeolog antikoerper, PAK3 antikoerper, Pak3 antikoerper, pak3.L antikoerper

Hintergrund:

Background: Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development.

Allen K.M., Nat. Genet. 20:25-30(1998).
Jiang C., Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
Kitano T., Mol. Biol. Evol. 20:1281-1289(2003).

Aliases: PAK3 antibody, OPHN3 antibody, Serine/threonine-protein kinase PAK 3 antibody, EC 2.7.11.1 antibody, Beta-PAK antibody, Oligophrenin-3 antibody, p21-activated kinase 3 antibody, PAK-3 antibody

UniProt: O75914