RPA2 Antikörper (Thr21)

Produktnummer ABIN7180080

Produktdetails anti-RPA2 Antikörper

Target: RPA2 (Replication Protein A2, 32kDa (RPA2))

Bindungsspezifität: Thr21

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RPA2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Kreuzreaktivität: Human, Maus

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized non-phosphopeptide derived from Human RFA2 around the phosphorylation site of threonine 21 (G-Y-T(p)-Q-S).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB:1:500-1:3000, IHC:1:50-1:100,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu RPA2

Target: RPA2 (Replication Protein A2, 32kDa (RPA2))

Andere Bezeichnung: RPA2 (RPA2 Produkte)

Synonyme: REPA2 antikoerper, RPA32 antikoerper, 153194_at antikoerper, CG9273 antikoerper, Dmel\\CG9273 antikoerper, dRPA2 antikoerper, rpa antikoerper, zgc:109822 antikoerper, ik:tdsubc_2g1 antikoerper, xx:tdsubc_2g1 antikoerper, repa2 antikoerper, rpa32 antikoerper, RPA2 antikoerper, GB13976 antikoerper, LOC100230445 antikoerper, AA409079 antikoerper, AI325195 antikoerper, AU020965 antikoerper, RPA34 antikoerper, Rf-A2 antikoerper, replication protein A2 antikoerper, Replication protein A2 antikoerper, replication protein A2, 32kDa antikoerper, replication protein A 32 kDa subunit antikoerper, RPA2 antikoerper, Rpa2 antikoerper, rpa2 antikoerper, LOC725418 antikoerper, RPA2_2 antikoerper

Hintergrund:

Background: As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage the RPA complex controls DNA repair and DNA damage checkpoint activation. It is required for the recruitment of the DNA double-strand break repair factors RAD52 and RAD51 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER) probably through interaction with UNG. Through RFWD3 may activate CHEK1 and play a role in replication checkpoint control. Also recruits SMARCAL1/HARP which is involved in replication fork restart to sites of DNA damage. May also play a role in telomere maintenance.

Erdile L.F., J. Biol. Chem. 265:3177-3182(1990).
Gregory S.G., Nature 441:315-321(2006).
Niu H., J. Biol. Chem. 272:12634-12641(1997).
Cho J.M., Nucleic Acids Res. 28:3478-3485(2000)

Aliases: 60S acidic ribosomal protein P1 antibody, AA409079 antibody, AI325195 antibody, AU020965 antibody, ik:tdsubc_2g1 antibody, M(2)21C antibody, MGC137236 antibody, OTTHUMP00000004008 antibody, p32 antibody, p34 antibody, RCJMB04_6d17 replication protein A2, 32 kDa antibody, REPA2 antibody, Replication factor A protein 2 antibody, Replication protein A 32 kDa subunit antibody, Replication protein A 32 kDa subunit antibody, Replication protein A 34 kDa subunit antibody, Replication protein A antibody, Replication Protein A2 (32 kDa) antibody, Replication protein A2 antibody, Replication protein A2, 32 kDa antibody, RF-A protein 2 antibody, Rf-A2 antibody, RFA antibody, RFA2_HUMAN antibody, RP-A p32 antibody, RP-A p34 antibody, RP21C antibody, RPA 2 antibody, RPA 32 antibody, RPA antibody, Rpa2 antibody, RPA32 antibody, RPA34 antibody, RpLP1 antibody, RpP2 antibody, xx:tdsubc_2g1 antibody, zgc:109822 antibody

UniProt: P15927

Pathways: Telomere Maintenance, DNA Reparatur, Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA