TK1 Antikörper (Ser13)

Produktnummer ABIN7180098

Produktdetails anti-TK1 Antikörper

Target: TK1 (Thymidine Kinase 1, Soluble (TK1))

Bindungsspezifität: Ser13

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TK1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Kreuzreaktivität: Human, Maus

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized non-phosphopeptide derived from Human TK around the phosphorylation site of serine 13 (P-G-S(p)-P-S).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu TK1

Target: TK1 (Thymidine Kinase 1, Soluble (TK1))

Andere Bezeichnung: TK1 (TK1 Produkte)

Synonyme: fi19b06 antikoerper, zgc:55362 antikoerper, wu:fi19b06 antikoerper, TK1 antikoerper, tk2 antikoerper, D530002A18Rik antikoerper, Tk-1 antikoerper, Tk1a antikoerper, Tk1b antikoerper, TK2 antikoerper, Tk antikoerper, TK antikoerper, thymidine kinase 1, soluble antikoerper, thymidine kinase 1 antikoerper, thymidine kinase, cytosolic antikoerper, Thymidine kinase, cytosolic antikoerper, temporal expression: early antikoerper, thymidine kinase antikoerper, Tk thymidine kinase antikoerper, tk1 antikoerper, TK1 antikoerper, EDI_049980 antikoerper, kith antikoerper, J2R antikoerper, HVT031 antikoerper, Tk1 antikoerper, tk antikoerper

Hintergrund:

Background: Thymidine kinases play a critical role in generating the DNA synthetic precursor deoxythymidine triphosphate (dTTP) by catalyzing the phosphotransfer of phosphate from ATP to deoxythymidine (dT) and thymidine (T) in the cell.TK1 expression and activity is regulated in a cell cycle-dependent manner, accumulating during G1-phase to peak levels in S-phase before being degraded prior to cell division. Stability, but not activity, may be regulated via phosphorylation of TK1 at Ser13 by Cdc2 and/or Cdk2, but the precise mode of regulation remains elusive. These observations indicate that TK1 might be a useful marker of cell proliferation, however, recent studies have shown that TK1 plays a more significant role in the DNA damage response.

N Singh, Mol. Cell. Biol., May 1991, 11: 2362 - 2374.
Bin Tian, Am. J. Pathol., Aug 2003, 163: 789.
RenGerolami, Cancer Res., Feb 2000, 60: 993 - 1001.
Catia Traversari, Blood, Jun 2007, 109: 4708 - 4715

Aliases: cytosolic antibody, KITH_HUMAN antibody, Thymidine kinase 1 antibody, Thymidine kinase 1 soluble antibody, Thymidine kinase 1 soluble isoform antibody, Thymidine kinase antibody, Thymidine kinase cytosolic antibody, TK 1 antibody, TK 2 antibody, TK1 antibody, Tk1a antibody, Tk1b antibody, TK2 antibody

UniProt: P04183