MASTL Antikörper (C-Term)

Produktnummer ABIN7180197

Produktdetails anti-MASTL Antikörper

Target: MASTL (Microtubule Associated serine/threonine Kinase-Like (MASTL))

Bindungsspezifität: C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MASTL Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Kreuzreaktivität: Human, Maus

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from C-terminal of Human MASTL.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB:1:500-1:3000,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu MASTL

Target: MASTL (Microtubule Associated serine/threonine Kinase-Like (MASTL))

Andere Bezeichnung: MASTL (MASTL Produkte)

Synonyme: GW antikoerper, GWL antikoerper, MAST-L antikoerper, im:7149025 antikoerper, wu:fa02a12 antikoerper, zgc:100990 antikoerper, MASTL antikoerper, GREATWALL antikoerper, RP11-85G18.2 antikoerper, THC2 antikoerper, hGWL antikoerper, 2700091H24Rik antikoerper, C88295 antikoerper, greatwall antikoerper, thc2 antikoerper, microtubule associated serine/threonine kinase-like antikoerper, microtubule associated serine/threonine kinase like antikoerper, serine/threonine-protein kinase greatwall antikoerper, microtubule associated serine/threonine kinase like L homeolog antikoerper, mastl antikoerper, MASTL antikoerper, LOC100541707 antikoerper, Mastl antikoerper, mastl.L antikoerper

Hintergrund:

Background: Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro, however such activity is unsure in vivo. May be involved in megakaryocyte differentiation.

Ota T., Nat. Genet. 36:40-45(2004).
Deloukas P., Nature 429:375-381(2004).
Beausoleil S.A., Nat. Biotechnol. 24:1285-1292(2006).

Aliases: 2700091H24Rik antibody, C88295 antibody, FLJ14813 antibody, GREATWALL antibody, Greatwall protein kinase antibody, GW antibody, GWL antibody, GWL_HUMAN antibody, hGWL antibody, MAST-L antibody, Mastl antibody, MGC117975 antibody, Microtubule associated serine/threonine kinase like antibody, Microtubule-associated serine/threonine-protein kinase-like antibody, RP11 85G18.2 antibody, Serine/threonine-protein kinase greatwall antibody, THC2 antibody

UniProt: Q96GX5