TUT1 Antikörper

Produktnummer ABIN7184310

Der Kaninchen Polyklonal Anti-TUT1-Antikörper wurde für WB, ELISA und IHC validiert. Er ist geeignet, TUT1 in Proben von Human zu detektieren.

Kurzübersicht für TUT1 Antikörper (ABIN7184310)

Target: TUT1 (Terminal Uridylyl Transferase 1, U6 SnRNA-Specific (TUT1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TUT1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-TUT1 Antikörper

Kreuzreaktivität: Human

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from internal of Human TUT1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB:1:500-1:3000, IHC:1:50-1:100,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu TUT1

Target: TUT1 (Terminal Uridylyl Transferase 1, U6 SnRNA-Specific (TUT1))

Andere Bezeichnung: TUT1

Hintergrund:

Background: Poly(A) polymerase that creates the 3'-poly(A) tail of specific pre-mRNAs. Localizes to nuclear speckles together with PIP5K1A and mediates polyadenylation of a select set of mRNAs, such as HMOX1. In addition to polyadenylation, it is also required for the 3'-end cleavage of pre-mRNAs: binds to the 3'UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3'UTR of pre-mRNAs. In addition to adenylyltransferase activity, also has uridylyltransferase activity. However, the ATP ratio is higher than UTP in cells, suggesting that it functions primarily as a poly(A) polymerase. Acts as a specific terminal uridylyltransferase for U6 snRNA in vitro: responsible for a controlled elongation reaction that results in the restoration of the four 3'-terminal UMP-residues found in newly transcribed U6 snRNA. Not involved in replication-dependent histone mRNA degradation.

Ota T., Nat. Genet. 36:40-45(2004).
The MGC Project Team, Genome Res. 14:2121-2127(2004).
Trippe R.,RNA 12:1494-1504(2006).

Aliases: alpha regulated poly(A) polymerase antibody, nuclear speckle targeted phosphatidylinositol 4 phosphate 5 kinase type I antibody, nuclear speckle targeted PIPK1A regulated poly(A) polymerase antibody, PAP associated domain containing 2 antibody, PAPD2 antibody, poly(A) polymerase associated domain containing 2 antibody, RBM21 antibody, RNA binding motif protein 21 antibody, RNA-binding motif protein 21 antibody, RNA-binding protein 21 antibody, Speckle targeted PIP5K1A-regulated poly(A) polymerase antibody, Star-PAP antibody, STARPAP antibody, STPAP_HUMAN antibody, terminal uridylyl transferase 1, U6 snRNA specific antibody, TUT1 antibody, TUTase antibody, U6 snRNA specific terminal uridylyltransferase 1 antibody, U6 snRNA-specific terminal uridylyltransferase 1 antibody, U6 TUTase antibody, U6-TUTase antibody, URLC6 antibody

UniProt: Q9H6E5