CHP Antikörper (N-Term)

Produktnummer ABIN7184426

Produktdetails anti-CHP Antikörper

Target: CHP (Calcium Binding Protein P22 (CHP))

Bindungsspezifität: N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CHP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from N-terminal of Human CHP.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB:1:500-1:3000,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu CHP

Target: CHP (Calcium Binding Protein P22 (CHP))

Andere Bezeichnung: CHP1 (CHP Produkte)

Synonyme: CHP antikoerper, SLC9A1BP antikoerper, Sid470p antikoerper, p22 antikoerper, p24 antikoerper, 1500003O03Rik antikoerper, AA960066 antikoerper, AI046351 antikoerper, Cahp antikoerper, Chp antikoerper, Wrch2 antikoerper, chp antikoerper, si:dkey-41n20.1 antikoerper, wu:fc69b04 antikoerper, zgc:63904 antikoerper, wu:fi19e07 antikoerper, zgc:55363 antikoerper, calcineurin like EF-hand protein 1 antikoerper, calcineurin-like EF hand protein 1 antikoerper, calcineurin-like EF-hand protein 1 antikoerper, calcineurin-like EF-hand protein 2 antikoerper, calcineurin-like EF-hand protein 1 L homeolog antikoerper, CHP1 antikoerper, Chp1 antikoerper, chp1 antikoerper, chp2 antikoerper, chp1.L antikoerper

Hintergrund:

Background: Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na+/H+ exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na+/H+ exchange activity. Affects the pH sensitivity of SLC9A1/NHE1 by increasing its sensitivity at acidic pH . Required for the stabilization and localization of SLC9A1/NHE1 at the plasma membrane. Inhibits serum- and GTPase-stimulated Na+/H+ exchange. Plays a role as an inhibitor of ribosomal RNA transcription by repressing the nucleolar UBF1 transcriptional activity. May sequester UBF1 in the nucleoplasm and limit its translocation to the nucleolus. Associates to the ribosomal gene promoter. Acts as a negative regulator of the calcineurin/NFAT signaling pathway. Inhibits NFAT nuclear translocation and transcriptional activity by suppressing the calcium-dependent calcineurin phosphatase activity. Also negatively regulates the kinase activity of the apoptosis-induced kinase STK17B. Inhibits both STK17B auto- and substrate-phosphorylations in a calcium-dependent manner.

Lin X., Proc. Natl. Acad. Sci. U.S.A. 93:12631-12636(1996).
Ebert L., Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Ota T., Nat. Genet. 36:40-45(2004).

Aliases: Calcineurin B homolog antibody, Calcineurin B homologous protein antibody, Calcineurin homologous protein antibody, Calcineurin like EF hand protein 1 antibody, Calcium binding protein CHP antibody, Calcium binding protein p22 antibody, Calcium-binding protein CHP antibody, Calcium-binding protein p22 antibody, chp antibody, CHP1_HUMAN antibody, Sid 470 antibody, Sid470 antibody, SLC9A1 binding protein antibody, SLC9A1BP antibody, Wrch2 antibody

UniProt: Q99653

Pathways: Proton Transport, Regulation of Carbohydrate Metabolic Process, VEGF Signaling