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PRKACA Antikörper (N-Term)

Der Kaninchen Polyklonal Anti-PRKACA-Antikörper wurde für WB und ELISA validiert. Er ist geeignet, PRKACA in Proben von Human zu detektieren.
Produktnummer ABIN7184469

Kurzübersicht für PRKACA Antikörper (N-Term) (ABIN7184469)

Target

Alle PRKACA Antikörper anzeigen
PRKACA (Protein Kinase A, alpha (PRKACA))

Reaktivität

  • 51
  • 37
  • 14
  • 4
  • 4
  • 4
  • 3
  • 3
  • 2
  • 2
  • 2
Human

Wirt

  • 55
  • 10
  • 2
  • 1
Kaninchen

Klonalität

  • 57
  • 11
Polyklonal

Konjugat

  • 42
  • 4
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser PRKACA Antikörper ist unkonjugiert

Applikation

  • 52
  • 27
  • 15
  • 13
  • 13
  • 11
  • 9
  • 5
  • 3
  • 3
  • 2
  • 2
  • 1
  • 1
Western Blotting (WB), ELISA
  • Bindungsspezifität

    • 15
    • 6
    • 5
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term

    Kreuzreaktivität

    Human, Maus, Ratte

    Aufreinigung

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

    Immunogen

    Synthesized peptide derived from N-terminal of Human KAPC A/B.

    Isotyp

    IgG
  • Applikationshinweise

    WB:1:500-1:3000,

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C,-80 °C

    Informationen zur Lagerung

    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target

    PRKACA (Protein Kinase A, alpha (PRKACA))

    Andere Bezeichnung

    PRKACA

    Hintergrund

    Background: Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the regulation of platelets in response to thrombin and collagen, maintains circulating platelets in a resting state by phosphorylating proteins in numerous platelet inhibitory pathways when in complex with NF-kappa-B (NFKB1 and NFKB2) and I-kappa-B-alpha (NFKBIA), but thrombin and collagen disrupt these complexes and free active PRKACA stimulates platelets and leads to platelet aggregation by phosphorylating VASP. Prevents the antiproliferative and anti-invasive effects of alpha-difluoromethylornithine in breast cancer cells when activated. RYR2 channel activity is potentiated by phosphorylation in presence of luminal Ca2+, leading to reduced amplitude and increased frequency of store overload-induced Ca2+ release (SOICR) characterized by an increased rate of Ca2+ release and propagation velocity of spontaneous Ca2+ waves, despite reduced wave amplitude and resting cytosolic Ca2+. PSMC5/RPT6 activation by phosphorylation stimulates proteasome. Negatively regulates tight junctions (TJs) in ovarian cancer cells via CLDN3 phosphorylation. NFKB1 phosphorylation promotes NF-kappa-B p50-p50 DNA binding. Involved in embryonic development by down-regulating the Hedgehog (Hh) signaling pathway that determines embryo pattern formation and morphogenesis. Prevents meiosis resumption in prophase-arrested oocytes via CDC25B inactivation by phosphorylation. May also regulate rapid eye movement (REM) sleep in the pedunculopontine tegmental (PPT). Phosphorylates APOBEC3G and AICDA. Isoform 2 phosphorylates and activates ABL1 in sperm flagellum to promote spermatozoa capacitation.

    Maldonado F., Nucleic Acids Res. 16:8189-8190(1988).
    Desseyn J.-L., Proc. Natl. Acad. Sci. U.S.A. 97:6433-6438(2000).
    Ficarro S., J. Biol. Chem. 278:11579-11589(2003).

    Aliases: cAMP dependent protein kinase alpha catalytic subunit antibody, cAMP dependent protein kinase beta catalytic subunit antibody, cAMP dependent protein kinase catalytic beta subunit isoform 4ab antibody, cAMP dependent protein kinase catalytic subunit alpha antibody, cAMP dependent protein kinase catalytic subunit alpha, isoform 1 antibody, cAMP dependent protein kinase catalytic subunit beta antibody, cAMP-dependent protein kinase catalytic subunit alpha antibody, KAPCA_HUMAN antibody, PKA C alpha antibody, PKA C beta antibody, PKA C-alpha antibody, PKACA antibody, PKACB antibody, PPNAD4 antibody, PRKACA antibody, PRKACAA antibody, PRKACB antibody, Protein kinase A catalytic subunit alpha antibody, Protein kinase A catalytic subunit antibody, Protein kinase A catalytic subunit beta antibody, Protein kinase, cAMP dependent, catalytic, alpha antibody, Protein kinase, cAMP dependent, catalytic, beta antibody

    UniProt

    P17612

    Pathways

    NF-kappaB Signalweg, Hedgehog Signalweg, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Thyroid Hormone Synthesis, Carbohydrate Homeostasis, Myometrial Relaxation and Contraction, M Phase, G-protein mediated Events, Signaling Events mediated by VEGFR1 and VEGFR2, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling, VEGFR1 Specific Signals, Lipid Metabolism, SARS-CoV-2 Protein Interaktom, Phosphorylierungen bei SARS-CoV-2 Infektion
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