Macrophage Scavenger Receptor 1 Antikörper (AA 275-451)
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- Target Alle Macrophage Scavenger Receptor 1 (MSR1) Antikörper anzeigen
- Macrophage Scavenger Receptor 1 (MSR1)
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Bindungsspezifität
- AA 275-451
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser Macrophage Scavenger Receptor 1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Flow Cytometry (FACS)
- Verwendungszweck
- CD204 Antibody
- Aufreinigung
- Purified antibody
- Immunogen
- Purified recombinant fragment of human CD204 (AA: 275-451) expressed in E. Coli.
- Klon
- 5B8H4
- Isotyp
- IgG1
- Top Product
- Discover our top product MSR1 Primärantikörper
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anti-Macrophage Scavenger Receptor 1 (MSR1) (AA 211-320) antibody
MSR1 Reaktivität: Human, Maus, Schaf WB, ELISA, FACS, IHC (fro), IF (cc), IF (p), IHC (p) Wirt: Kaninchen Polyclonal unconjugated
anti-Macrophage Scavenger Receptor 1 (MSR1) (N-Term) antibodyMSR1 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Macrophage Scavenger Receptor 1 (MSR1) antibodyMSR1 Reaktivität: Human WB, IHC Wirt: Kaninchen Monoclonal unconjugated
anti-Macrophage Scavenger Receptor 1 (MSR1) (AA 271-446) antibodyMSR1 Reaktivität: Human WB, ELISA, IHC Wirt: Kaninchen Polyclonal unconjugated
anti-Macrophage Scavenger Receptor 1 (MSR1) (AA 336-364), (C-Term) antibodyMSR1 Reaktivität: Human, Maus WB Wirt: Kaninchen Polyclonal RB36746 unconjugated
anti-Macrophage Scavenger Receptor 1 (MSR1) antibodyMSR1 Reaktivität: Maus, Schwein, Catfish (Ictalurus) WB, ELISA, FACS, IHC (fro), IP Wirt: Ratte Monoclonal 2F8 unconjugated
anti-Macrophage Scavenger Receptor 1 (MSR1) (AA 121-220) antibodyMSR1 Reaktivität: Human WB, ELISA Wirt: Maus Monoclonal 2G9 unconjugated
anti-Macrophage Scavenger Receptor 1 (MSR1) antibodyMSR1 Reaktivität: Human, Maus, Ratte IF Wirt: Kaninchen Polyclonal unconjugated
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- Applikationshinweise
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ELISA: 1/10000
FCM: 1/200 - 1/400
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- Purified antibody in PBS with 0.05 % sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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- Target
- Macrophage Scavenger Receptor 1 (MSR1)
- Andere Bezeichnung
- CD204 (MSR1 Produkte)
- Hintergrund
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Description:
This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages.
Aliases: MSR1, SRA, SR-A, SR-AI, phSR1, phSR2, SCARA1, SR-AII, SR-AIII
- Molekulargewicht
- 49.8kDa
- Gen-ID
- 4481
- UniProt
- P21757
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