CXCR2 Antikörper

Produktnummer ABIN7193273

Produktdetails anti-CXCR2 Antikörper

Target: CXCR2 (Chemokine (C-X-C Motif) Receptor 2 (CXCR2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CXCR2 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Verwendungszweck: CD182 Antibody

Aufreinigung: Purified antibody

Immunogen: Purified recombinant fragment of human CD182 expressed in E. Coli.

Klon: 7E9H12

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

ELISA: 1/10000

FCM: 1/200 - 1/400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Details zu CXCR2

Target: CXCR2 (Chemokine (C-X-C Motif) Receptor 2 (CXCR2))

Andere Bezeichnung: CD182 (CXCR2 Produkte)

Synonyme: CD182 antikoerper, CDw128b antikoerper, CMKAR2 antikoerper, IL8R2 antikoerper, IL8RA antikoerper, IL8RB antikoerper, CXC-R2 antikoerper, CXCR-2 antikoerper, CD128 antikoerper, CDw128 antikoerper, Cmkar2 antikoerper, Gpcr16 antikoerper, IL-8Rh antikoerper, IL-8rb antikoerper, Il8rb antikoerper, mIL-8RH antikoerper, C-X-C motif chemokine receptor 2 antikoerper, chemokine (C-X-C motif) receptor 2 antikoerper, Cxcr2 antikoerper, CXCR2 antikoerper

Hintergrund:

Description:

The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified.

Aliases: CXCR2, IL8R2, IL8RA, IL8RB, CMKAR2, CDw128b

Molekulargewicht: 40.8kDa

Gen-ID: 3579

UniProt: P25025

Pathways: cAMP Metabolic Process