MTA1 Antikörper (AA 541-715)

Produktnummer ABIN7193369

Produktdetails anti-MTA1 Antikörper

Target: MTA1 (Metastasis Associated 1 (MTA1))

Bindungsspezifität: AA 541-715

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MTA1 Antikörper ist unkonjugiert

Applikation: ELISA, Flow Cytometry (FACS)

Verwendungszweck: MTA1 Antibody

Aufreinigung: Purified antibody

Immunogen: Purified recombinant fragment of human MTA1 (AA: 541-715) expressed in E. Coli.

Klon: 7G9C10

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise:

ELISA: 1/10000

FCM: 1/200 - 1/400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Details zu MTA1

Target: MTA1 (Metastasis Associated 1 (MTA1))

Andere Bezeichnung: MTA1 (MTA1 Produkte)

Synonyme: Tex22 antikoerper, metastasis associated 1 antikoerper, metastasis associated 1 L homeolog antikoerper, MTA1 antikoerper, Mta1 antikoerper, mta1.L antikoerper

Hintergrund:

This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

Molekulargewicht: 80.8kDa

Gen-ID: 9112

UniProt: Q13330

Pathways: Chromatin Binding