SETD7 Antikörper (AA 107-366)

Produktnummer ABIN7193392

Produktdetails anti-SETD7 Antikörper

Target: SETD7 (SET Domain Containing (Lysine Methyltransferase) 7 (SETD7))

Bindungsspezifität: AA 107-366

Reaktivität: Human, Ratte, Affe

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SETD7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunocytochemistry (ICC), Neutralization (Neut)

Aufreinigung: purified

Immunogen: Purified recombinant fragment of human SETD7 (AA: 107-366) expressed in E. coli.

Klon: 1B3B8

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: ELISA: 1:10000, WB: 1:500 - 1:2000, FCM: 1:200 - 1:400, ICC: N/A, IHC: N/A

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Purified antibody in PBS with 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: 4°C, -20°C for long term storage

Details zu SETD7

Target: SETD7 (SET Domain Containing (Lysine Methyltransferase) 7 (SETD7))

Andere Bezeichnung: SETD7 (SETD7 Produkte)

Synonyme: KMT7 antikoerper, SET7 antikoerper, SET7/9 antikoerper, SET9 antikoerper, set7 antikoerper, zgc:101860 antikoerper, zgc:92330 antikoerper, 1600028F23Rik antikoerper, H3K4MT antikoerper, Set7 antikoerper, Set7/9 antikoerper, mKIAA1717 antikoerper, SET domain containing lysine methyltransferase 7 antikoerper, SET domain containing (lysine methyltransferase) 7 antikoerper, SETD7 antikoerper, setd7 antikoerper, Setd7 antikoerper

Hintergrund:

Description: Histone methyltransferase that specifically monomethylates Lys-4 of histone H3. H3 Lys-4 methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates Lys-189 of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates Lys-372 of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.

Aliases: KMT7, SET7, SET9, SET7/9

Molekulargewicht: 40.7 kDa

Gen-ID: 80854