ATR Antikörper (AA 366-550)

Produktnummer ABIN7193431

Produktdetails anti-ATR Antikörper

Target: ATR (ATR serine/threonine kinase (ATR))

Bindungsspezifität: AA 366-550

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ATR Antikörper ist unkonjugiert

Applikation: ELISA, Flow Cytometry (FACS)

Verwendungszweck: ATR Antibody

Aufreinigung: Purified antibody

Immunogen: Purified recombinant fragment of human ATR (AA: 366-550) expressed in E. Coli.

Klon: 3G6D2

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

ELISA: 1/10000

FCM: 1/200 - 1/400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Details zu ATR

Target: ATR (ATR serine/threonine kinase (ATR))

Andere Bezeichnung: ATR (ATR Produkte)

Synonyme: FCTCS antikoerper, FRP1 antikoerper, MEC1 antikoerper, SCKL antikoerper, SCKL1 antikoerper, ATR serine/threonine kinase antikoerper, ataxia telangiectasia and Rad3 related antikoerper, ATR antikoerper, Atr antikoerper

Hintergrund:

Description:

The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1.

Aliases: FRP1, MEC1, SCKL, FCTCS, SCKL1

Molekulargewicht: 301kDa

Gen-ID: 545

UniProt: Q13535

Pathways: Positive Regulation of Response to DNA Damage Stimulus