DFFA Antikörper (AA 179-331)
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- Target Alle DFFA Antikörper anzeigen
- DFFA (DNA Fragmentation Factor, 45kDa, alpha Polypeptide (DFFA))
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Bindungsspezifität
- AA 179-331
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser DFFA Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Flow Cytometry (FACS)
- Aufreinigung
- purified
- Immunogen
- Purified recombinant fragment of human DFFA (AA: 179-331) expressed in E. coli.
- Klon
- 2B10C8
- Isotyp
- IgG1
- Top Product
- Discover our top product DFFA Primärantikörper
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- Applikationshinweise
- WB:1:500 - 1:2000, FCM:1:200 - 1:400, ELISA:1:10000,
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Buffer
- Purified antibody in PBS with 0.05 % sodium azide
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- 4°C, -20°C for long term storage
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- Target
- DFFA (DNA Fragmentation Factor, 45kDa, alpha Polypeptide (DFFA))
- Andere Bezeichnung
- DFFA (DFFA Produkte)
- Synonyme
- DFF-45 antikoerper, DFF1 antikoerper, ICAD antikoerper, A330085O09Rik antikoerper, DFF35 antikoerper, Dff45 antikoerper, ICAD-L antikoerper, ICAD-S antikoerper, DFFA antikoerper, zgc:92229 antikoerper, DNA fragmentation factor subunit alpha antikoerper, DNA fragmentation factor, alpha subunit antikoerper, DNA fragmentation factor, 45kDa, alpha polypeptide antikoerper, DNA fragmentation factor, alpha polypeptide antikoerper, DFFA antikoerper, Dffa antikoerper, dffa antikoerper
- Hintergrund
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Description: Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Aliases: DFF1, ICAD, DFF-45
- Molekulargewicht
- 36.5 kDa
- Gen-ID
- 1676
- Pathways
- Apoptose, Caspase Kaskade in der Apoptose
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