LIFR Antikörper (AA 22-441)

Produktnummer ABIN7193531

Produktdetails anti-LIFR Antikörper

Target: LIFR (Leukemia Inhibitory Factor Receptor alpha (LIFR))

Bindungsspezifität: AA 22-441

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser LIFR Antikörper ist unkonjugiert

Applikation: ELISA, Flow Cytometry (FACS)

Verwendungszweck: CD118 Antibody

Aufreinigung: Purified antibody

Immunogen: Purified recombinant fragment of human PLA2G7 (AA: 22-441) expressed in E. Coli.

Klon: 5D3G12

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

ELISA: 1/10000

FCM: 1/200 - 1/400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Details zu LIFR

Target: LIFR (Leukemia Inhibitory Factor Receptor alpha (LIFR))

Andere Bezeichnung: CD118 (LIFR Produkte)

Synonyme: A230075M04Rik antikoerper, AW061234 antikoerper, LIF antikoerper, CD118 antikoerper, LIF-R antikoerper, SJS2 antikoerper, STWS antikoerper, SWS antikoerper, leukemia inhibitory factor receptor antikoerper, LIF receptor alpha antikoerper, leukemia inhibitory factor receptor alpha antikoerper, Lifr antikoerper, LOC397451 antikoerper, LIFR antikoerper

Hintergrund:

Description:

This gene encodes a protein that belongs to the type I cytokine receptor family. This protein combines with a high-affinity converter subunit, gp130, to form a receptor complex that mediates the action of the leukemia inhibitory factor, a polyfunctional cytokine that is involved in cellular differentiation, proliferation and survival in the adult and the embryo. Mutations in this gene cause Schwartz-Jampel syndrome type 2, a disease belonging to the group of the bent-bone dysplasias. A translocation that involves the promoter of this gene, t(5,8)(p13,q12) with the pleiomorphic adenoma gene 1, is associated with salivary gland pleiomorphic adenoma, a common type of benign epithelial tumor of the salivary gland. Multiple splice variants encoding two different isoforms have been found for this gene.

Aliases: LIFR, SWS, SJS2, STWS, LIF-R

Molekulargewicht: 123.7kDa

Gen-ID: 3977

UniProt: P42702

Pathways: JAK-STAT Signalweg, Growth Factor Binding