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MLH1 Antikörper (AA 381-483)

Name: MLH1 Antikörper (AA 381-483)
Brand: antibodies-online
SKU: ABIN7193587
Price: 614.71 EUR
Availability: InStock

MLH1 Reaktivität: Human WB, ELISA, IHC, FACS Wirt: Maus Monoclonal 7A7C8 unconjugated

Western blot analysis using MLH1 mAb against human MLH1 (AA: 381-483) recombinant protein. (MLH1 Antikörper (AA 381-483))

Immunohistochemical analysis of paraffin-embedded bladder cancer tissues using MLH1 mouse mAb with DAB staining. (MLH1 Antikörper (AA 381-483))

IHC

Black line: Control Antigen (100 ng),Purple line: Antigen (10 ng), Blue line: Antigen (50 ng), Red line:Antigen (100 ng) (MLH1 Antikörper (AA 381-483))

ELISA

Western blot analysis using MLH1 mAb against HEK293 (1) and MLH1 (AA: 381-483)-hIgGFc transfected HEK293 (2) cell lysate. (MLH1 Antikörper (AA 381-483))

Western blot analysis using MLH1 mouse mAb against Hela (1), Jurkat (2), A431 (3), HepG2 (4), and MCF-7 (5) cell lysate. (MLH1 Antikörper (AA 381-483))

Flow cytometric analysis of Hela cells using MLH1 mouse mAb (green) and negative control (red). (MLH1 Antikörper (AA 381-483))

FACS

Immunohistochemical analysis of paraffin-embedded colon cancer tissues using MLH1 mouse mAb with DAB staining. (MLH1 Antikörper (AA 381-483))

IHC

7 Abbildungen

Produktnummer ABIN7193587

Datenblatt (PDF)

Target Alle MLH1 Antikörper anzeigen

MLH1 (MutL Homolog 1 (MLH1))
Bindungsspezifität
15

10

9

8

7

6

4

3

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 381-483
Reaktivität
83

22

21

4

3

2

2

2

2

2

2

2

2

1

1

1
Human
Wirt
67

16
Maus
Passende Sekundärantikörper
Klonalität
62

21
Monoklonal
Konjugat
48

5

5

4

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
Dieser MLH1 Antikörper ist unkonjugiert
Applikation
47

34

18

13

13

11

11

8

6

5

3

2

2

2

2

1

1

1
Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Verwendungszweck

MLH1 Antibody

Aufreinigung

Purified antibody

Immunogen

Purified recombinant fragment of human MLH1 (AA:381-483) expressed in E. Coli.

Klon

7A7C8

Isotyp

IgG1

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Applikationshinweise

ELISA: 1/10000
FCM: 1/200-1/400

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Liquid

Buffer

Purified antibody in PBS with 0.05 % sodium azide.

Konservierungsmittel

Sodium azide

Vorsichtsmaßnahmen

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung

4 °C,-20 °C

Informationen zur Lagerung

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Target

MLH1 (MutL Homolog 1 (MLH1))

Andere Bezeichnung

MLH1 (MLH1 Produkte)

Synonyme

CG11482 antikoerper, Dmel\\CG11482 antikoerper, dmlh-1 antikoerper, dmlh1 antikoerper, zgc:66301 antikoerper, MLH1 antikoerper, LOC100232198 antikoerper, 1110035C23Rik antikoerper, AI317206 antikoerper, AI325952 antikoerper, AI561766 antikoerper, COCA2 antikoerper, FCC2 antikoerper, HNPCC antikoerper, HNPCC2 antikoerper, hMLH1 antikoerper, mutL homolog 1 antikoerper, CG11482 gene product from transcript CG11482-RB antikoerper, mutL homolog 1 S homeolog antikoerper, mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) antikoerper, DNA mismatch repair protein Mlh1 antikoerper, MLH1 antikoerper, Mlh1 antikoerper, mlh1.S antikoerper, mlh1 antikoerper, LOC588545 antikoerper

Hintergrund

Description:
The protein encoded by this gene can heterodimerize with mismatch repair endonuclease PMS2 to form MutL alpha, part of the DNA mismatch repair system. When MutL alpha is bound by MutS beta and some accessory proteins, the PMS2 subunit of MutL alpha introduces a single-strand break near DNA mismatches, providing an entry point for exonuclease degradation. The encoded protein is also involved in DNA damage signaling and can heterodimerize with DNA mismatch repair protein MLH3 to form MutL gamma, which is involved in meiosis. This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). [provided by RefSeq, Aug 2017]
Aliases: FCC2, COCA2, HNPCC, hMLH1, HNPCC2

Molekulargewicht

84.6kDa

Gen-ID

4292

UniProt

P40692

Pathways

DNA Reparatur, Production of Molecular Mediator of Immune Response