WT1 Antikörper (AA 1-181)
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- Target Alle WT1 Antikörper anzeigen
- WT1 (Wilms Tumor 1 (WT1))
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Bindungsspezifität
- AA 1-181
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser WT1 Antikörper ist unkonjugiert
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Applikation
- Flow Cytometry (FACS), Immunohistochemistry (IHC), Western Blotting (WB), ELISA, Immunocytochemistry (ICC)
- Verwendungszweck
- WT1 Antibody
- Aufreinigung
- Purified antibody
- Immunogen
- Purified recombinant fragment of human WT1 (AA: 1-181) expressed in E. Coli.
- Klon
- 7F9E8
- Isotyp
- IgG1
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- Applikationshinweise
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ELISA: 1/10000
FCM: 1/200-1/400
ICC: 1/200 - 1/1000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- Purified antibody in PBS with 0.05 % sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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- Target
- WT1 (Wilms Tumor 1 (WT1))
- Andere Bezeichnung
- WT1 (WT1 Produkte)
- Hintergrund
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Description:
This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation codon upstream of, and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated.
Aliases: GUD, AWT1, WAGR, WT33, NPHS4, WIT-2
- Molekulargewicht
- 49.2kDa
- Gen-ID
- 7490
- UniProt
- P19544
- Pathways
- Tube Formation
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