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USP28 Antikörper (AA 101-200)

USP28 Reaktivität: Maus WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN715241
  • Target Alle USP28 Antikörper anzeigen
    USP28 (Ubiquitin Specific Peptidase 28 (USP28))
    Bindungsspezifität
    • 14
    • 8
    • 7
    • 7
    • 7
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    AA 101-200
    Reaktivität
    • 41
    • 16
    • 2
    • 1
    • 1
    Maus
    Wirt
    • 52
    • 2
    • 1
    Kaninchen
    Klonalität
    • 55
    Polyklonal
    Konjugat
    • 17
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser USP28 Antikörper ist unkonjugiert
    Applikation
    • 31
    • 19
    • 13
    • 12
    • 12
    • 5
    • 4
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Kreuzreaktivität
    Maus
    Homologie
    Human,Rat
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human USP28
    Isotyp
    IgG
    Top Product
    Discover our top product USP28 Primärantikörper
  • Applikationshinweise
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Haltbarkeit
    12 months
  • Target
    USP28 (Ubiquitin Specific Peptidase 28 (USP28))
    Andere Bezeichnung
    USP28 (USP28 Produkte)
    Synonyme
    im:7138195 antikoerper, USP28 antikoerper, 9830148O20Rik antikoerper, AU022237 antikoerper, mKIAA1515 antikoerper, ubiquitin specific peptidase 28 antikoerper, USP28 antikoerper, usp28 antikoerper, Usp28 antikoerper
    Hintergrund

    Synonyms: Deubiquitinating enzyme 28, KIAA1515, Ubiquitin carboxyl terminal hydrolase 28, Ubiquitin carboxyl-terminal hydrolase 28, Ubiquitin specic peptidase 28, Ubiquitin specic processing protease 28, Ubiquitin specic protease 28, Ubiquitin thioesterase 28, Ubiquitin thiolesterase 28, Ubiquitin-specic-processing protease 28, UBP28_HUMAN, USP 28, USP28, USP28 protein, USP-28.

    Background: Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C). In contrast, it does not deubiquitinate PLK1. Specifically deubiquitinates MYC in the nucleoplasm, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 4 of FBXW7 (FBW7gamma) in the nucleolus, allowing MYC degradation and explaining the selective MYC degradation in the nucleolus.

    Gen-ID
    57646
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