Sclerostin Antikörper
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- Target Alle Sclerostin (SOST) Antikörper anzeigen
- Sclerostin (SOST)
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Reaktivität
- Human, Maus, Ratte, Hund, Schwein
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser Sclerostin Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Kreuzreaktivität
- Hund, Human, Maus, Schwein, Ratte
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human Sclerostin
- Isotyp
- IgG
- Top Product
- Discover our top product SOST Primärantikörper
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anti-Sclerostin (SOST) (AA 12-42), (N-Term) antibody
SOST Reaktivität: Human, Maus, Ratte WB, IHC (p) Wirt: Kaninchen Polyclonal RB12388 unconjugated
anti-Sclerostin (SOST) (AA 25-213) antibodySOST Reaktivität: Human WB, IHC, IP, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Sclerostin (SOST) (AA 24-213) antibodySOST Reaktivität: Human WB, IHC, ELISA Wirt: Kaninchen Polyclonal unconjugated
anti-Sclerostin (SOST) (AA 24-213) antibodySOST Reaktivität: Human IHC, ELISA Wirt: Kaninchen Polyclonal unconjugated
anti-Sclerostin (SOST) (AA 121-180) antibodySOST Reaktivität: Human, Maus, Ratte, Kaninchen WB, ELISA, IF (p), ICC, IHC (p), IF (cc), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
anti-Sclerostin (SOST) (AA 134-163) antibodySOST Reaktivität: Human WB, IHC (p) Wirt: Kaninchen Polyclonal RB13011 unconjugated
anti-Sclerostin (SOST) (AA 38-66), (N-Term) antibodySOST Reaktivität: Human, Maus WB Wirt: Kaninchen Polyclonal RB36187 unconjugated
anti-Sclerostin (SOST) (N-Term) antibodySOST Reaktivität: Human, Maus WB, IHC (p), EIA Wirt: Kaninchen Polyclonal unconjugated
anti-Sclerostin (SOST) (AA 25-209) antibodySOST Reaktivität: Maus WB, IHC, IP, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Sclerostin (SOST) antibodySOST Reaktivität: Human IHC Wirt: Kaninchen Polyclonal unconjugated
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- Applikationshinweise
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WB(1:100-500)
Optimal working dilution should be determined by the investigator. - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C for 12 months.
- Haltbarkeit
- 12 months
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- Target
- Sclerostin (SOST)
- Andere Bezeichnung
- Sclerostin (SOST Produkte)
- Synonyme
- LOC100313724 antikoerper, CDD antikoerper, VBCH antikoerper, 5430411E23Rik antikoerper, sclerostin antikoerper, LOC100313724 antikoerper, SOST antikoerper, Sost antikoerper
- Hintergrund
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Synonyms: BEER, Cortical hyperostosis with syndactyly, Sclerosteosis, Sclerostin, SOST, SOST_HUMAN, VBCH.
Background: Negative regulator of bone growth.Sclerostin (SOST) is a bone morphogenetic protein (BMP) antagonist, leading to the activation of BMP signaling. It negatively regulates the formation of bone by repressing the differentiation and/or function of osteoblasts induced by BMPs. It has been shown that Sclerostin binds BMP-5, -6, and -7 with high affinity and BMP-2 and -4 with low affinity. The noggin-sclerostin protein complex represents a novel mechanism for the fine-tuning of BMP activity in bone homeostasis. Evidence is accumulating that one of the important mechanisms of bone regulation by sclerostin is the modulation of Wnt/Beta-catenin signaling. Sclerostin also rapidly activated ERK-1/2 MAPK signaling, indicating the involvement of additional signaling pathways.
- Molekulargewicht
- 24-28kDa
- Gen-ID
- 50964
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