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Rekombinanter MS4A1 (Rituximab Biosimilar) Antikörper

Reaktivität: Human FACS, in vivo Wirt: Maus Monoclonal 10F381 unconjugated Recombinant Antibody
Produktnummer ABIN7200660
  • Target Alle MS4A1 (Rituximab Biosimilar) Produkte
    MS4A1 (Rituximab Biosimilar)
    Antikörpertyp
    Recombinant Antibody
    Reaktivität
    • 4
    • 2
    • 2
    Human
    Wirt
    • 1
    • 1
    • 1
    • 1
    Maus
    Klonalität
    • 3
    • 1
    Monoklonal
    Konjugat
    • 4
    Dieser MS4A1 (Rituximab Biosimilar) Antikörper ist unkonjugiert
    Applikation
    Flow Cytometry (FACS), In vivo Studies (in vivo)
    Verwendungszweck
    Rituximab Biosimilar, CD20 Monoclonal Antibody
    Spezifität
    The monoclonal antibody rituximab biosimilar specifically binds to the human TNF alpha.
    Produktmerkmale
    Recombinant Humanized IgG1 Monoclonal Antibody.
    Aufreinigung
    Protein A affinity column
    Reinheit
    > 95% by SDS-PAGE under reducing conditions and HPLC.
    Sterilität
    0.2 μm filtered
    Endotoxin-Niveau
    < 1 EU per 1 mg of the protein by the LAL method.
    Immunogen
    The monoclonal antibody rituximab biosimilar was produced in the Rituximab biosimilar CHO stable cell line.
    Klon
    10F381
    Isotyp
    IgG1 kappa
  • Applikationshinweise
    ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by rituximab.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    PBS, pH 7.4, no stabilizers or preservatives.
    Konservierungsmittel
    Without preservative
    Handhabung
    Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    12 months from date of receipt, -20 to -70°C as supplied. 1 month from date of receipt, 2 to 8°C as supplied.
    Haltbarkeit
    12 months
  • Target
    MS4A1 (Rituximab Biosimilar)
    Abstract
    MS4A1 (Rituximab Biosimilar) Produkte
    Synonyme
    B1 antikoerper, Bp35 antikoerper, CD20 antikoerper, CVID5 antikoerper, LEU-16 antikoerper, MS4A2 antikoerper, S7 antikoerper, membrane spanning 4-domains A1 antikoerper, MS4A1 antikoerper
    Substanzklasse
    Biosimilar
    Hintergrund
    B-lymphocyte antigen CD20 encoded by the MS4A1 gene is an activated-glycosylated phosphoprotein on the surface of all B-cells. The function of the membrane protein is to stimulate B-cell immune response, specifically against T-independent antigens though its natural ligand remains unknown. CD20 is important for the development and differentiation of B-cells into plasma cells. CD20 belongs to the membrane-spanning 4A family with common structural features, similar intron/exon splice boundaries, and unique expression patterns among hematopoietic cells and nonlymphoid tissues.

    Rituximab, a chimeric anti-CD20 monoclonal antibody, destroys B cells and is used to treat diseases with excessive numbers of B cells, overactive B cells, or dysfunctional B cells, such as many lymphomas, leukemias, transplant rejection, and autoimmune disorders.
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