APAF1 Antikörper (Internal Region)

Produktnummer ABIN7218288

Produktdetails anti-APAF1 Antikörper

Target: APAF1 (Apoptotic Peptidase Activating Factor 1 (APAF1))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser APAF1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Verwendungszweck: Apaf-1 Polyclonal Antibody

Spezifität: Apaf-1 Polyclonal Antibody detects endogenous levels of Apaf-1 protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from the Internal region of human Apaf-1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), ELISA (1:20000). Not yet tested in other applications.

Kommentare:

Primary Antibody

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Details zu APAF1

Target: APAF1 (Apoptotic Peptidase Activating Factor 1 (APAF1))

Andere Bezeichnung: Apaf-1 (APAF1 Produkte)

Synonyme: APAF1 antikoerper, ARK antikoerper, Apaf-1 antikoerper, Apaf1 antikoerper, CG6829 antikoerper, D-Apaf-1 antikoerper, DARK antikoerper, Dapaf-1 antikoerper, Dapaf-1/HAC-1 antikoerper, Dark antikoerper, Dark/Apaf-I antikoerper, Dark/Dapaf-1/HAC1 antikoerper, Dark/Hac-1/dApaf-1 antikoerper, Dark/Hac-1/dApaf1 antikoerper, Dmel\\CG6829 antikoerper, Hac-1 antikoerper, Hac-1/Dark antikoerper, Hac1 antikoerper, T1 antikoerper, anon-53Fa antikoerper, apaf-1 antikoerper, apaf1 antikoerper, arc antikoerper, ark antikoerper, dAPAF-1 antikoerper, dApaf-1 antikoerper, dApaf-1/DARK/HAC-1 antikoerper, dApaf1 antikoerper, dArk antikoerper, dapaf antikoerper, dapaf-1 antikoerper, dapaf-1L antikoerper, dapaf-1S antikoerper, dark antikoerper, dark/dapaf-1/hac-1 antikoerper, dark/hac-1/dapaf-1 antikoerper, hac-1 antikoerper, hac1 antikoerper, l(2)SH0173 antikoerper, APAF-1 antikoerper, CED4 antikoerper, 6230400I06Rik antikoerper, Apaf1l antikoerper, fog antikoerper, mKIAA0413 antikoerper, zgc:136543 antikoerper, Death-associated APAF1-related killer antikoerper, apoptotic peptidase activating factor 1 L homeolog antikoerper, apoptotic peptidase activating factor 1 antikoerper, Dark antikoerper, apaf1.L antikoerper, apaf1 antikoerper, APAF1 antikoerper, Apaf1 antikoerper

Hintergrund: Rabbit Anti-Apaf-1 Polyclonal Antibody,APAF1, KIAA0413, Apoptotic protease-activating factor 1, APAF-1,APAF1 encodes a cytoplasmic protein that initiates apoptosis. Apoptotic protease-activating factor 1 contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms.,Apoptotic protease-activating factor 1

Gen-ID: 317

UniProt: O14727

Pathways: p53 Signalweg, Apoptose, Caspase Kaskade in der Apoptose, Tube Formation, Positive Regulation of Endopeptidase Activity