MLKL Antikörper (pSer358)

Produktnummer ABIN7212282

Produktdetails anti-MLKL Antikörper

Target: MLKL (Mixed Lineage Kinase Domain-Like (MLKL))

Bindungsspezifität: pSer358

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MLKL Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Verwendungszweck: phospho-MLKL (S358) Mouse Monoclonal Antibody (6F8)

Spezifität: Phospho-MLKL (S358) protein detects endogenous levels of MLKL.

Aufreinigung: The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen

Immunogen: Synthetic Peptide of phospho-MLKL (S358)

Klon: 6F8

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC-P (1:100-1:200).

Kommentare:

Primary Antibody

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Details zu MLKL

Target: MLKL (Mixed Lineage Kinase Domain-Like (MLKL))

Andere Bezeichnung: MLKL (MLKL Produkte)

Synonyme: MLKL antikoerper, 9130019I15Rik antikoerper, mixed lineage kinase domain like pseudokinase antikoerper, mixed lineage kinase domain-like antikoerper, MLKL antikoerper, mlkl antikoerper, Mlkl antikoerper

Hintergrund: Mouse Anti-phospho-MLKL (S358) Mouse Monoclonal Antibody (6F8),MLKL,MLKL (mixed lineage kinase domain like) belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain, however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF) -induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of MLKL inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for MLKL.,MLKL

Molekulargewicht: observerd band 54kDa

Gen-ID: 197259

UniProt: Q8NB16