ABI2 Antikörper (AA 100-200)
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- Target Alle ABI2 Antikörper anzeigen
- ABI2 (Abl-Interactor 2 (ABI2))
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Bindungsspezifität
- AA 100-200
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser ABI2 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Verwendungszweck
- ABI2 Rabbit pAb
- Sequenz
- HKEKVARREI GILTTNKNTS RTHKIIAPAN LERPVRYIRK PIDYTILDDI GHGVKWLLRF KVSTQNMKMG GLPRTTPPTQ KPPSPPMSGK GTLGRHSPYR T
- Kreuzreaktivität
- Human, Maus
- Produktmerkmale
- Polyclonal Antibodies
- Aufreinigung
- Affinity purification
- Immunogen
- A synthetic peptide corresponding to a sequence within amino acids 100-200 of human ABI2 (NP_001269854.1).
- Isotyp
- IgG
- Top Product
- Discover our top product ABI2 Primärantikörper
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- Applikationshinweise
- WB,1:500 - 1:2000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- ABI2 (Abl-Interactor 2 (ABI2))
- Andere Bezeichnung
- ABI2 (ABI2 Produkte)
- Synonyme
- ABI-2 antikoerper, ABI2B antikoerper, AIP-1 antikoerper, AblBP3 antikoerper, SSH3BP2 antikoerper, argBPIA antikoerper, argBPIB antikoerper, 8430425M24Rik antikoerper, AI839867 antikoerper, C130078H13 antikoerper, abl interactor 2 antikoerper, abl-interactor 2 antikoerper, ABI2 antikoerper, abi2 antikoerper, Abi2 antikoerper
- Hintergrund
- Regulator of actin cytoskeleton dynamics underlying cell motility and adhesion. Functions as a component of the WAVE complex, which activates actin nucleating machinery Arp2/3 to drive lamellipodia formation. Acts as regulator and substrate of nonreceptor tyrosine kinases ABL1 and ABL2 involved in processes linked to cell growth and differentiation. Positively regulates ABL1-mediated phosphorylation of ENAH, which is required for proper polymerization of nucleated actin filaments at the leading edge. Contributes to the regulation of actin assembly at the tips of neuron projections. In particular, controls dendritic spine morphogenesis and may promote dendritic spine specification toward large mushroom-type spines known as repositories of memory in the brain (By similarity. In hippocampal neurons, may mediate actin-dependent BDNF-NTRK2 early endocytic trafficking that triggers dendrite outgrowth (By similarity. Participates in ocular lens morphogenesis, likely by regulating lamellipodia-driven adherens junction formation at the epithelial cell-secondary lens fiber interface (By similarity. Also required for nascent adherens junction assembly in epithelial cells.,ABI2,ABI-2,ABI2B,AIP-1,AblBP3,SSH3BP2,argBP1,argBPIA,argBPIB,Cancer,Tumor suppressors,ABI2
- Molekulargewicht
- 44kDa/52kDa/54kDa/55kDa
- Gen-ID
- 10152
- UniProt
- Q9NYB9
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