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AKT 1/2/3 Antikörper (pSer472)

Reaktivität: Human WB Wirt: Kaninchen Monoclonal unconjugated
Produktnummer ABIN7265522
  • Target Alle AKT 1/2/3 Produkte
    AKT 1/2/3
    Bindungsspezifität
    • 22
    • 21
    • 20
    • 20
    • 19
    • 19
    • 17
    • 16
    • 16
    • 16
    • 7
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer472
    Reaktivität
    • 147
    • 141
    • 127
    • 44
    • 31
    • 26
    • 23
    • 15
    • 7
    • 6
    • 4
    • 4
    Human
    Wirt
    • 145
    • 2
    Kaninchen
    Klonalität
    • 136
    • 11
    Monoklonal
    Konjugat
    • 35
    • 7
    • 7
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser AKT 1/2/3 Antikörper ist unkonjugiert
    Applikation
    • 127
    • 79
    • 78
    • 77
    • 33
    • 27
    • 25
    • 18
    • 7
    • 7
    • 6
    Western Blotting (WB)
    Verwendungszweck
    Phospho-AKT1-S473+AKT2-S474+AKT3-S472 Rabbit mAb
    Kreuzreaktivität
    Human, Maus, Ratte
    Produktmerkmale
    Phosphorylated Antibodies
    Aufreinigung
    Affinity purification
    Immunogen
    A phospho specific peptide corresponding to residues surrounding S473/S474/S472 of human AKT1/AKT2/AKT3
    Isotyp
    IgG
  • Applikationshinweise
    WB,1:500 - 1:1000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    AKT 1/2/3
    Andere Bezeichnung
    AKT1/AKT2/AKT3 (AKT 1/2/3 Produkte)
    Hintergrund
    The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011],AKT1/AKT2/AKT3,Protein phosphorylation,Protein phosphorylation,Protein phosphorylation,AKT1/AKT2/AKT3
    Molekulargewicht
    48kDa/55kDa/51kDa/54kDa
    Gen-ID
    207, 208, 10000
    UniProt
    P31749, P31751, Q9Y243
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