ALK Antikörper (AA 19-300)

Produktnummer ABIN7529465

Produktdetails anti-ALK Antikörper

Target: ALK (Anaplastic Lymphoma Receptor tyrosine Kinase (ALK))

Bindungsspezifität: AA 19-300

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ALK Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Verwendungszweck: ALK Rabbit pAb

Sequenz: VGSGMGTGQR AGSPAAGPPL QPREPLSYSR LQRKSLAVDF VVPSLFRVYA RDLLLPPSSS ELKAGRPEAR GSLALDCAPL LRLLGPAPGV SWTAGSPAPA EARTLSRVLK GGSVRKLRRA KQLVLELGEE AILEGCVGPP GEAAVGLLQF NLSELFSWWI RQGEGRLRIR LMPEKKASEV GREGRLSAAI RASQPRLLFQ IFGTGHSSLE SPTNMPSPSP DYFTWNLTWI MKDSFPFLSH RSRYGLECSF DFPCELEYSP PLHDLRNQSW SWRRIPSEEA SQ

Kreuzreaktivität: Human, Maus

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 19-300 of human ALK (NP_004295.2).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:1000,IHC,1:50 - 1:100,IF,1:50 - 1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu ALK

Target: ALK (Anaplastic Lymphoma Receptor tyrosine Kinase (ALK))

Andere Bezeichnung: ALK (ALK Produkte)

Synonyme: Tcrz antikoerper, CD246 antikoerper, NBLST3 antikoerper, ALK antikoerper, anaplastic lymphoma kinase antikoerper, anaplastic lymphoma receptor tyrosine kinase antikoerper, ALK receptor tyrosine kinase antikoerper, Alk antikoerper, ALK antikoerper

Hintergrund: This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).,ALK,CD246,NBLST3,Cancer,Signal Transduction,Kinase,Tyrosine kinases,Cell Biology & Developmental Biology,Growth factor,Immunology & Inflammation,CD markers,Neuroscience,Cell Type Marker,Neuron marker,ALK

Molekulargewicht: 176kDa

Gen-ID: 238

UniProt: Q9UM73

Pathways: RTK Signalweg