Chromosome 7 Open Reading Frame 20 (C7orf20) (AA 1-327) Antikörper

Produktnummer ABIN7266388

Produktdetails

Target: Chromosome 7 Open Reading Frame 20 (C7orf20)

Bindungsspezifität: AA 1-327

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: Western Blotting (WB)

Verwendungszweck: GET4 Rabbit pAb

Sequenz: MAAAAAMAEQ ESARNGGRNR GGVQRVEGKL RASVEKGDYY EAHQMYRTLF FRYMSQSKHT EARELMYSGA LLFFSHGQQN SAADLSMLVL ESLEKAEVEV ADELLENLAK VFSLMDPNSP ERVTFVSRAL KWSSGGSGKL GHPRLHQLLA LTLWKEQNYC ESRYHFLHSA DGEGCANMLV EYSTSRGFRS EVDMFVAQAV LQFLCLKNKS SASVVFTTYT QKHPSIEDGP PFVEPLLNFI WFLLLAVDGG KLTVFTVLCE QYQPSLRRDP MYNEYLDRIG QLFFGVPPKQ TSSYGGLLGN LLTSLMGSSE QEDGEESPSD GSPIELD

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-327 of human GET4 (NP_057033.2).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Antigendetails

Target: Chromosome 7 Open Reading Frame 20 (C7orf20)

Andere Bezeichnung: GET4 (C7orf20 Produkte)

Synonyme: cee antikoerper, cgi-20 antikoerper, c7orf20 antikoerper, get4 antikoerper, C7orf20 antikoerper, CEE antikoerper, TRC35 antikoerper, 1110007L15Rik antikoerper, AW412535 antikoerper, Cee antikoerper, RGD1311660 antikoerper, C25H7ORF20 antikoerper, get4-a antikoerper, golgi to ER traffic protein 4 antikoerper, chromosome 7 open reading frame 20 antikoerper, Cee antikoerper, golgi to ER traffic protein 4 homolog (S. cerevisiae) antikoerper, golgi to ER traffic protein 4 S homeolog antikoerper, get4 antikoerper, Bm1_33940 antikoerper, LOC100136505 antikoerper, GET4 antikoerper, Get4 antikoerper, get4.S antikoerper

Hintergrund: As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum. Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome. Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum. The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD, a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome.,GET4,C7orf20,CEE,CGI-20,TRC35,Cell Biology & Developmental Biology,GET4

Molekulargewicht: 30kDa/36kDa

Gen-ID: 51608

UniProt: Q7L5D6