C9ORF72 Antikörper (AA 1-230)

Produktnummer ABIN7266391

Produktdetails anti-C9ORF72 Antikörper

Target: C9ORF72 (Chromosome 9 Open Reading Frame 72 (C9ORF72))

Bindungsspezifität: AA 1-230

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser C9ORF72 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Verwendungszweck: C9orf72 Rabbit pAb

Sequenz: MSTLCPPPSP AVAKTEIALS GKSPLLAATF AYWDNILGPR VRHIWAPKTE QVLLSDGEIT FLANHTLNGE ILRNAESGAI DVKFFVLSEK GVIIVSLIFD GNWNGDRSTY GLSIILPQTE LSFYLPLHRV CVDRLTHIIR KGRIWMHKER QENVQKIILE GTERMEDQGQ SIIPMLTGEV IPVMELLSSM KSHSVPEEID IADTVLNDDD IGDSCHEGFL LNAISSHLQT

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human C9orf72 (NP_060795.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IHC,1:50 - 1:100,IF,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu C9ORF72

Target: C9ORF72 (Chromosome 9 Open Reading Frame 72 (C9ORF72))

Andere Bezeichnung: C9orf72 (C9ORF72 Produkte)

Synonyme: CZH9orf72 antikoerper, ALSFTD antikoerper, FTDALS antikoerper, AI840585 antikoerper, c9orf72 antikoerper, chromosome Z C9orf72 homolog antikoerper, chromosome 9 open reading frame 72 antikoerper, RIKEN cDNA 3110043O21 gene antikoerper, similar to RIKEN cDNA 3110043O21 antikoerper, chromosome 9 open reading frame 72 L homeolog antikoerper, CZH9orf72 antikoerper, C9orf72 antikoerper, 3110043O21Rik antikoerper, RGD1359108 antikoerper, c9orf72.L antikoerper

Hintergrund: The protein encoded by this gene plays an important role in the regulation of endosomal trafficking, and has been shown to interact with Rab proteins that are involved in autophagy and endocytic transport. Expansion of a GGGGCC repeat from 2-22 copies to 700-1600 copies in the intronic sequence between alternate 5' exons in transcripts from this gene is associated with 9p-linked ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia) (PMID: 21944778, 21944779). Studies suggest that hexanucleotide expansions could result in the selective stabilization of repeat-containing pre-mRNA, and the accumulation of insoluble dipeptide repeat protein aggregates that could be pathogenic in FTD-ALS patients (PMID: 23393093). Alternative splicing results in multiple transcript variants encoding different isoforms.,C9orf72,ALSFTD,DENNL72,FTDALS,FTDALS1,Epigenetics & Nuclear Signaling,Transcription Factors,Neuroscience,Neurodegenerative Diseases,Neurodegenerative Diseases Markers,Other Neurological disorders,Amyotrophic lateral sclerosis-ALS,C9orf72

Molekulargewicht: 24kDa/54kDa

Gen-ID: 203228

UniProt: Q96LT7