BcDNA:LD14270 antikoerper, CAS antikoerper, CG13281 antikoerper, Dcas antikoerper, Dmel\\CG13281 antikoerper, cas antikoerper, dcas antikoerper, l(2)k03902 antikoerper, CSE1L antikoerper, XPO2 antikoerper, Exportin-2 antikoerper, DKFZp459E1929 antikoerper, 2610100P18Rik antikoerper, AA407533 antikoerper, Capts antikoerper, Cas antikoerper, Xpo2 antikoerper, xpo2 antikoerper, CSE1 antikoerper, CAS/CSE1 segregation protein antikoerper, chromosome segregation 1 like antikoerper, exportin-2 antikoerper, chromosome segregation 1-like (S. cerevisiae) antikoerper, CSE1 chromosome segregation 1-like (yeast) antikoerper, CSE1 chromosome segregation 1-like L homeolog antikoerper, Cas antikoerper, CSE1L antikoerper, LOC100542094 antikoerper, cse1l antikoerper, Cse1l antikoerper, cse1l.L antikoerper
Hintergrund
Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012],CAS, CSE1, XPO2,Apoptosis,Cell Biology & Developmental Biology,Signal Transduction,CSE1L