CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. [provided by RefSeq, Mar 2016],DNMT3A,DNMT3A2,M.HsaIIIA,TBRS,DNMT3A,Epigenetic writers and erasers of core Histones,Epigenetic writers and erasers of core Histones_DNA methylation,Epigenetics & Nuclear Signaling,DNMT3A