FURIN Antikörper

Produktnummer ABIN7267277

Produktdetails anti-FURIN Antikörper

Target: FURIN (Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser FURIN Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP)

Verwendungszweck: Furin Rabbit mAb

Kreuzreaktivität: Human, Maus

Produktmerkmale: Monoclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: A synthesized peptide derived from human Furin

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IP,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu FURIN

Target: FURIN (Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN))

Andere Bezeichnung: FURIN (FURIN Produkte)

Synonyme: FURIN antikoerper, furin antikoerper, si:dkey-281a24.5 antikoerper, FUR antikoerper, LOC100220259 antikoerper, PACE antikoerper, spc1 antikoerper, xfurin antikoerper, MGC82710 antikoerper, PCSK3 antikoerper, SPC1 antikoerper, 9130404I01Rik antikoerper, Fur antikoerper, Pcsk3 antikoerper, Pace antikoerper, furin, paired basic amino acid cleaving enzyme antikoerper, furin (paired basic amino acid cleaving enzyme) a antikoerper, furin (paired basic amino acid cleaving enzyme) b antikoerper, furin, paired basic amino acid cleaving enzyme L homeolog antikoerper, furin (paired basic amino acid cleaving enzyme) antikoerper, FURIN antikoerper, furina antikoerper, furinb antikoerper, furin antikoerper, furin.L antikoerper, Furin antikoerper

Hintergrund: This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. The product of this gene is one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is also thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140 and may play a role in tumor progression. This gene is located in close proximity to family member proprotein convertase subtilisin/kexin type 6 and upstream of the FES oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014],FUR, PACE, PCSK3, SPC1,Cell Adhesion,Cell Biology & Developmental Biology,Cytoskeleton,Endocrine & Metabolism,Notch Signaling Pathway,Signal Transduction,Ubiquitin,FURIN

Molekulargewicht: 87kDa

Gen-ID: 5045

UniProt: P09958

Pathways: Notch Signalweg, Neurotrophin Signalübertragung