FGD5 Antikörper (AA 1000-1200)

Produktnummer ABIN7267286

Produktdetails anti-FGD5 Antikörper

Target: FGD5 (FYVE, RhoGEF and PH Domain Containing 5 (FGD5))

Bindungsspezifität: AA 1000-1200

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FGD5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Verwendungszweck: FGD5 Rabbit pAb

Sequenz: YLGLLSENCL HSPRLAAAVR EFEQSVQGGS QTAKHRLLRV VQRLFQYQVL LTDYLNNLCP DSAEYDNTQG ALSLISKVTD RANDSMEQGE NLQKLVHIEH SVRGQGDLLQ PGREFLKEGT LMKVTGKNRR PRHLFLMNDV LLYTYPQKDG KYRLKNTLAV ANMKVSRPVM EKVPYALKIE TSESCLMLSA SSCAERDEWY G

Kreuzreaktivität: Maus

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1000-1200 of human FGD5 (NP_689749.3).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu FGD5

Target: FGD5 (FYVE, RhoGEF and PH Domain Containing 5 (FGD5))

Andere Bezeichnung: FGD5 (FGD5 Produkte)

Synonyme: ZFYVE23 antikoerper, C330025N11Rik antikoerper, mFLJ00274 antikoerper, FYVE, RhoGEF and PH domain containing 5 antikoerper, Fgd5 antikoerper, FGD5 antikoerper

Hintergrund: FGD5 (or ZFYVE23) is an endothelial specific gene, plays a crucial role in vascular pruning. Deficient expression of FGD5 markedly inhibits neovascularization, indicated by in vitro tube-formation, aortic-ring, and coated-bead assays and by in vivo coated-bead plug assays and studies in the murine retina model. FGD5-deficient endothelial cells fail to migrate. Moreover, the cells are susceptible to proapoptotic stimuli associated with VEGF-stimulated activation of Akt. FGD5 promotes apoptosis-induced vaso-obliteration via induction of the hey1-p53 pathway by direct binding and activation of CDC42.,FGD5,ZFYVE23,FYVE,Signal Transduction,G protein signaling,Signal Transduction,FGD5

Molekulargewicht: 61kDa/159kDa

Gen-ID: 152273

UniProt: Q6ZNL6