GCK Antikörper (AA 250-465)

Produktnummer ABIN7267397

Produktdetails anti-GCK Antikörper

Target: GCK (Glucokinase (Hexokinase 4) (GCK))

Bindungsspezifität: AA 250-465

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GCK Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Verwendungszweck: Glucokinase (GCK) Rabbit pAb

Sequenz: RMCVNTEWGA FGDSGELDEF LLEYDRLVDE SSANPGQQLY EKLIGGKYMG ELVRLVLLRL VDENLLFHGE ASEQLRTRGA FETRFVSQVE SDTGDRKQIY NILSTLGLRP STTDCDIVRR ACESVSTRAA HMCSAGLAGV INRMRESRSE DVMRITVGVD GSVYKLHPSF KERFHASVRR LTPSCEITFI ESEEGSGRGA ALVSAVACKK ACMLGQ

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 250-465 of human Glucokinase (Glucokinase (GCK)) (NP_000153.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu GCK

Target: GCK (Glucokinase (Hexokinase 4) (GCK))

Andere Bezeichnung: GCK (GCK Produkte)

Synonyme: FGQTL3 antikoerper, GK antikoerper, GLK antikoerper, HHF3 antikoerper, HK4 antikoerper, HKIV antikoerper, HXKP antikoerper, LGLK antikoerper, MODY2 antikoerper, Gk antikoerper, Gls006 antikoerper, GCK antikoerper, BA4487 antikoerper, glk antikoerper, hk4 antikoerper, hhf3 antikoerper, hkiv antikoerper, hxkp antikoerper, gck-A antikoerper, mody2 antikoerper, glucokinase antikoerper, GLUKA antikoerper, RNGK2 antikoerper, glucokinase antikoerper, glucokinase (hexokinase 4) L homeolog antikoerper, glucokinase (hexokinase 4) antikoerper, GCK antikoerper, Gck antikoerper, glcK antikoerper, Bphyt_1025 antikoerper, Halhy_6548 antikoerper, gk antikoerper, gck.L antikoerper, gck antikoerper

Hintergrund: Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI).,GCK,FGQTL3,GK,GLK,HHF3,HK4,HKIV,HXKP,LGLK,MODY2,Cancer,Signal Transduction,Endocrine & Metabolism,Carbohydrate metabolism,Warburg Effect,GCK

Molekulargewicht: 52kDa

Gen-ID: 2645

UniProt: P35557

Pathways: MAPK Signalweg, Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis, Cellular Glucan Metabolic Process, Regulation of Carbohydrate Metabolic Process