8430435N19Rik antikoerper, BB233594 antikoerper, GRAP antikoerper, grap antikoerper, zgc:110202 antikoerper, MGC109892 antikoerper, si:dkeyp-9d4.1 antikoerper, Grap antikoerper, GRB2-related adaptor protein antikoerper, GRB2-related adapter protein antikoerper, GRB2-related adaptor protein a antikoerper, GRB2-related adaptor protein b antikoerper, GRAP antikoerper, Grap antikoerper, LOC489534 antikoerper, grapa antikoerper, grapb antikoerper, LOC100727005 antikoerper
Hintergrund
This gene encodes a member of the GRB2/Sem5/Drk family and functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain. In general, it couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway.,GRAP,Signal Transduction,G protein signaling,Signal Transduction,GRAP