IFI35 Antikörper (AA 1-288)

Produktnummer ABIN7267962

Produktdetails anti-IFI35 Antikörper

Target: IFI35 (Interferon-Induced Protein 35 (IFI35))

Bindungsspezifität: AA 1-288

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IFI35 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Verwendungszweck: IFI35 Rabbit pAb

Sequenz: MSAPLDAALH ALQEEQARLK MRLWDLQQLR KELGDSPKDK VPFSVPKIPL VFRGHTQQDP EVPKSLVSNL RIHCPLLAGS ALITFDDPKV AEQVLQQKEH TINMEECRLR VQVQPLELPM VTTIQVMMSS QLSGRRVLVT GFPASLRLSE EELLDKLEIF FGKTRNGGGD VDVRELLPGS VMLGFARDGV AQRLCQIGQF TVPLGGQQVP LRVSPYVNGE IQKAEIRSQP VPRSVLVLNI PDILDGPELH DVLEIHFQKP TRGGGEVEAL TVVPQGQQGL AVFTSESG

Kreuzreaktivität: Human, Maus

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-288 of human IFI35 (NP_005524.2).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IF,1:50 - 1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu IFI35

Target: IFI35 (Interferon-Induced Protein 35 (IFI35))

Andere Bezeichnung: IFI35 (IFI35 Produkte)

Synonyme: IFI35 antikoerper, IFP35 antikoerper, 2010008K16Rik antikoerper, AW986054 antikoerper, ifi-35 antikoerper, interferon induced protein 35 antikoerper, interferon-induced protein 35 antikoerper, IFI35 antikoerper, ifi35 antikoerper, Ifi35 antikoerper

Hintergrund: Acts as a signaling pathway regulator involved in innate immune system response. In response to interferon IFN-alpha, associates in a complex with signaling pathway regulator NMI to regulate immune response, the complex formation prevents proteasome-mediated degradation of IFI35 and correlates with IFI35 dephosphorylation. In complex with NMI, inhibits virus-triggered type I interferon/IFN-beta production. In complex with NMI, negatively regulates nuclear factor NF-kappa-B signaling by inhibiting the nuclear translocation, activation and transcription of the NF-kappa-B subunit p65/RELA, resulting in the inhibition of endothelial cell proliferation, migration and re-endothelialization of injured arteries. Beside its role as an intracellular signaling pathway regulator, also functions extracellularly as damage-associated molecular patterns (DAMPs to promote inflammation when actively released by macrophage to the extracellular space during cell injury and pathogen invasion. Macrophage-secreted IFI35 activates NF-kappa-B signaling in adjacent macrophages through Toll-like receptor 4/TLR4 activation, thereby inducing NF-kappa-B translocation from the cytoplasm into the nucleus which promotes the release of proinflammatory cytokines.,IFI35,IFP35,Cell Biology & Developmental Biology,Apoptosis,Cell Cycle,Cell differentiation,IFI35

Molekulargewicht: 31kDa

Gen-ID: 3430

UniProt: P80217