LAPTM4B Antikörper (AA 218-317)

Produktnummer ABIN7268341

Produktdetails anti-LAPTM4B Antikörper

Target: LAPTM4B (Lysosomal Protein Transmembrane 4 beta (LAPTM4B))

Bindungsspezifität: AA 218-317

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LAPTM4B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Verwendungszweck: LAPTM4B Rabbit pAb

Sequenz: NSIQEYIRQL PPNFPYRDDV MSVNPTCLVL IILLFISIIL TFKGYLISCV WNCYRYINGR NSSDVLVYVT SNDTTVLLPP YDDATVNGAA KEPPPPYVSA

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 218-317 of human LAPTM4B (NP_060877.3).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu LAPTM4B

Target: LAPTM4B (Lysosomal Protein Transmembrane 4 beta (LAPTM4B))

Andere Bezeichnung: LAPTM4B (LAPTM4B Produkte)

Synonyme: LAPTM4beta antikoerper, LC27 antikoerper, C330023P13Rik antikoerper, lysosomal protein transmembrane 4 beta antikoerper, lysosomal-associated protein transmembrane 4B antikoerper, LAPTM4B antikoerper, Laptm4b antikoerper

Hintergrund: Required for optimal lysosomal function. Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation. Recruits SLC3A2 and SLC7A5 (the Leu transporter to the lysosome, promoting entry of leucine and other essential amino acid (EAA into the lysosome, stimulating activation of proton-transporting vacuolar (V-ATPase protein pump (V-ATPase and hence mTORC1 activation. Plays a role as negative regulator of TGFB1 production in regulatory T cells. Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways.,LAPTM4B,LAPTM4beta,LC27,Cancer,Tumor biomarkers,LAPTM4B

Molekulargewicht: 25kDa/35kDa/41kDa

Gen-ID: 55353

UniProt: Q86VI4