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MAML2 Antikörper (AA 750-850)

MAML2 Reaktivität: Human WB, IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7268410
  • Target Alle MAML2 Antikörper anzeigen
    MAML2 (Mastermind-Like 2 (MAML2))
    Bindungsspezifität
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 750-850
    Reaktivität
    • 26
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Human
    Wirt
    • 16
    • 11
    Kaninchen
    Klonalität
    • 16
    • 11
    Polyklonal
    Konjugat
    • 17
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser MAML2 Antikörper ist unkonjugiert
    Applikation
    • 22
    • 12
    • 10
    • 9
    • 9
    • 7
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Verwendungszweck
    MAML2 Rabbit pAb
    Sequenz
    NQQLMGKKQT LQRQIMEQKQ QLLLQQQMLA DAEKIAPQDQ INRHLSRPPP DYKDQRRNVG NMQPTAQYSG GSSTISLNSN QALANPVSTH TILTPNSSLL S
    Kreuzreaktivität
    Human, Maus, Ratte
    Produktmerkmale
    Polyclonal Antibodies
    Aufreinigung
    Affinity purification
    Immunogen
    A synthetic peptide corresponding to a sequence within amino acids 750-850 of human MAML2 (NP_115803.1).
    Isotyp
    IgG
    Top Product
    Discover our top product MAML2 Primärantikörper
  • Applikationshinweise
    WB,1:500 - 1:2000,IF,1:50 - 1:200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    MAML2 (Mastermind-Like 2 (MAML2))
    Andere Bezeichnung
    MAML2 (MAML2 Produkte)
    Synonyme
    5930431H10 antikoerper, BC032967 antikoerper, MAM-3 antikoerper, MAM2 antikoerper, MAM3 antikoerper, MLL-MAML2 antikoerper, mastermind like 2 (Drosophila) antikoerper, mastermind-like transcriptional coactivator 2 antikoerper, mastermind like transcriptional coactivator 2 antikoerper, Maml2 antikoerper, MAML2 antikoerper
    Hintergrund
    The protein encoded by this gene is a member of the Mastermind-like family of proteins. All family members are proline and glutamine-rich, and contain a conserved basic domain that binds the ankyrin repeat domain of the intracellular domain of the Notch receptors (ICN1-4) in their N-terminus, and a transcriptional activation domain in their C-terminus. This protein binds to an extended groove that is formed by the interaction of CBF1, Suppressor of Hairless, LAG-1 (CSL) with ICN, and positively regulates Notch signaling. High levels of expression of this gene have been observed in several B cell-derived lymphomas. Translocations resulting in fusion proteins with both CRTC1 and CRTC3 have been implicated in the development of mucoepidermoid carcinomas, while a translocation event with CXCR4 has been linked with chronic lymphocytic leukemia (CLL). Copy number variation in the polyglutamine tract has been observed.,MAML2,MAM-3,MAM2,MAM3,MLL-MAML2,Epigenetics & Nuclear Signaling,Signal Transduction,Cell Biology & Developmental Biology,Notch Signaling Pathway,Stem Cells,MAML2
    Gen-ID
    84441
    UniProt
    Q8IZL2
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