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OMA1 Antikörper (AA 360-524)

OMA1 Reaktivität: Human WB, IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7269095
  • Target Alle OMA1 Antikörper anzeigen
    OMA1 (OMA1 Zinc Metallopeptidase Homolog (OMA1))
    Bindungsspezifität
    • 15
    • 5
    • 1
    • 1
    AA 360-524
    Reaktivität
    • 22
    • 17
    • 17
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Wirt
    • 22
    Kaninchen
    Klonalität
    • 22
    Polyklonal
    Konjugat
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser OMA1 Antikörper ist unkonjugiert
    Applikation
    • 18
    • 13
    • 13
    • 7
    • 3
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Verwendungszweck
    OMA1 Rabbit pAb
    Sequenz
    AICPRDSLAL LCQWIQSKLQ EYMFNRPYSR KLEAEADKIG LLLAAKACAD IRASSVFWQQ MEFVDSLHGQ PKMPEWLSTH PSHGNRVEYL DRLIPQALKI REMCNCPPLS NPDPRLLFKL STKHFLEESE KEDLNITKKQ KMDTLPIQKQ EQIPLTYIVE KRTGS
    Kreuzreaktivität
    Human, Maus, Ratte
    Produktmerkmale
    Polyclonal Antibodies
    Aufreinigung
    Affinity purification
    Immunogen
    Recombinant fusion protein containing a sequence corresponding to amino acids 360-524 of human OMA1 (NP_660286.1).
    Isotyp
    IgG
    Top Product
    Discover our top product OMA1 Primärantikörper
  • Applikationshinweise
    WB,1:500 - 1:2000,IF,1:50 - 1:100
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    OMA1 (OMA1 Zinc Metallopeptidase Homolog (OMA1))
    Andere Bezeichnung
    OMA1 (OMA1 Produkte)
    Synonyme
    2010001O09Rik antikoerper, DAB1 antikoerper, MPRP-1 antikoerper, YKR087C antikoerper, ZMPOMA1 antikoerper, peptidase antikoerper, RGD1304821 antikoerper, oma1 antikoerper, OMA1 zinc metallopeptidase antikoerper, si:ch73-215a11.1 antikoerper, olfactory receptor 4K2 antikoerper, OMA1 antikoerper, Oma1 antikoerper, si:ch73-215a11.1 antikoerper, LOC531304 antikoerper
    Hintergrund
    Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Activated in response to various mitochondrial stress, leading to the proteolytic cleavage of target proteins, such as OPA1, UQCC3 and DELE1. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1 position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion. Also acts as a regulator of apoptosis: upon BAK and BAX aggregation, mediates cleavage of OPA1, leading to the remodeling of mitochondrial cristae and allowing the release of cytochrome c from mitochondrial cristae. In depolarized mitochondria, may also act as a backup protease for PINK1 by mediating PINK1 cleavage and promoting its subsequent degradation by the proteasome. May also cleave UQCC3 in response to mitochondrial depolarization. Also acts as an activator of the integrated stress response (ISR: in response to mitochondrial stress, mediates cleavage of DELE1 to generate the processed form of DELE1 (S-DELE1, which translocates to the cytosol and activates EIF2AK1/HRI to trigger the ISR. Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions (By similarity. Binds cardiolipin, possibly regulating its protein turnover (By similarity. Required for the stability of the respiratory supercomplexes (By similarity.,OMA1,2010001O09Rik,DAB1,MPRP-1,MPRP1,YKR087C,ZMPOMA1,peptidase,Cell Biology & Developmental Biology,Ubiquitin,Endocrine & Metabolism,Mitochondrial metabolism,Mitochondrial markers,OMA1
    Molekulargewicht
    60kDa/55kDa
    Gen-ID
    115209
    UniProt
    Q96E52
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