SARS-Coronavirus Nonstructural Protein 8 (SARS-CoV NSP8) Antikörper

Produktnummer ABIN7270150

Produktdetails

Target: SARS-Coronavirus Nonstructural Protein 8 (SARS-CoV NSP8)

Reaktivität: SARS Coronavirus-2 (SARS-CoV-2)

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Unkonjugiert

Applikation: Immunofluorescence (IF), Western Blotting (WB)

Verwendungszweck: SARS-CoV-2 3CLpro Rabbit mAb

Kreuzreaktivität: SARS Coronavirus-2 (SARS-CoV-2)

Produktmerkmale: Monoclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein of SARS-CoV-2 3CLpro.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IF,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Antigendetails

Target: SARS-Coronavirus Nonstructural Protein 8 (SARS-CoV NSP8)

Andere Bezeichnung: 3CLpro (SARS-CoV NSP8 Produkte)

Synonyme: pp1a antikoerper, pp1ab antikoerper, orf1ab polyprotein (pp1ab) antikoerper, orf1ab antikoerper

Substanzklasse: Viral Protein

Hintergrund: [Spike protein S1]: attaches the virion to the cell membrane by interacting with host receptor, initiating the infection. Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein. Binding to host NRP1 and NRP2 via C-terminal polybasic sequence enhances virion entry into host cell. This interaction may explain virus tropism of human olfactory epithelium cells, which express high level of NRP1 and NRP2 but low level of ACE2. The stalk domain of S contains three hinges, giving the head unexpected orientational freedom. Uses human TMPRSS2 for priming in human lung cells which is an essential step for viral entry. Can be alternatively processed by host furin. Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.,3CLpro

Gen-ID: 43740578

UniProt: P0DTC2