SPRY3 Antikörper (C-Term)

Produktnummer ABIN7270556

Produktdetails anti-SPRY3 Antikörper

Target: SPRY3 (Sprouty Homolog 3 (SPRY3))

Bindungsspezifität: C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SPRY3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Verwendungszweck: SPRY3 Rabbit pAb

Sequenz: TDDEDNCADE PCSCGPSSCF VRWAAMSLIS LFLPCLCCYL PTRGCLHLCQ QGYDSLRRPG CRCKRHTNTV CRKISSGSAP FPKAQEKSV

Kreuzreaktivität: Human

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human SPRY3 (NP_005831.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu SPRY3

Target: SPRY3 (Sprouty Homolog 3 (SPRY3))

Andere Bezeichnung: SPRY3 (SPRY3 Produkte)

Synonyme: HSPRY3 antikoerper, spry-3 antikoerper, Gm1409 antikoerper, Gm391 antikoerper, sprouty3 antikoerper, RGD1562172 antikoerper, sprouty RTK signaling antagonist 3 antikoerper, sprouty homolog 3 (Drosophila) antikoerper, SPRY3 antikoerper, Spry3 antikoerper

Hintergrund: Members of the Sprouty family (Sprouty 1-4) are inducible negative regulators of growth factors that act through tyrosine kinase receptors. Mammalian Sprouty homologs share a well-conserved cysteine-rich carboxy-terminal domain with their Drosophila counterparts. Sprouty proteins are cytoplasmic in unstimulated cells, but in cells stimulated by growth factors they anchor to the plasma membrane by palmitoylation. Sprouty 1 and 2 associate with caveolin-1 in perinuclear and vesicular structures and are phosphorylated on serine residues. Sprouty 2 can associate with c-Cbl, a downregulator of RTK signaling, and inhibit the activities of several growth factors. Unlike the widely expressed Sprouty members 1, 2 and 4, Sprouty 3 expression is restricted to adult brain and testis. Sprouty 4 is a target of the WNT/b-catenin signaling pathway in progenitor cells. In conclusion, members of Sprouty inhibit FGF and VEGF-mediated cell proliferation, suggesting that they may regulate angiogenesis in normal and disease processes.,SPRY3,spry-3,Signal Transduction,ErbB-HER Signaling Pathway,MAPK-Erk Signaling Pathway,Cell Biology & Developmental Biology,Growth factor,SPRY3

Molekulargewicht: 31kDa

Gen-ID: 10251

UniProt: O43610