SARM1 Antikörper

Produktnummer ABIN7270591

Produktdetails anti-SARM1 Antikörper

Target: SARM1 (Sterile alpha and TIR Motif Containing 1 (SARM1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SARM1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP)

Verwendungszweck: SARM1 Rabbit pAb

Kreuzreaktivität: Human

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant protein of human SARM1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IP,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu SARM1

Target: SARM1 (Sterile alpha and TIR Motif Containing 1 (SARM1))

Andere Bezeichnung: SARM1 (SARM1 Produkte)

Synonyme: A830091I15Rik antikoerper, C78606 antikoerper, MyD885 antikoerper, Sarm antikoerper, MyD88-5 antikoerper, SAMD2 antikoerper, SARM antikoerper, sterile alpha and TIR motif containing 1 antikoerper, sterile alpha and HEAT/Armadillo motif containing 1 antikoerper, SARM1 antikoerper, Sarm1 antikoerper, sarm1 antikoerper

Hintergrund: NAD(+ hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+ metabolism. Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death which involves degeneration of an axon distal to the injury site. Wallerian degeneration is triggered by NAD(+ depletion: in response to injury, SARM1 is activated and catalyzes cleavage of NAD(+ into ADP-D-ribose (ADPR, cyclic ADPR (cADPR and nicotinamide, NAD(+ cleavage promoting cytoskeletal degradation and axon destruction. Also able to hydrolyze NADP(+, but not other NAD(+-related molecules. Can activate neuronal cell death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway (By similarity. Involved in innate immune response: inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38.,SARM, HsTIR, SAMD2, hSARM1, MyD88-5,SARM1

Molekulargewicht: 79kDa

Gen-ID: 23098

UniProt: Q6SZW1

Pathways: TLR Signalweg, Activation of Innate immune Response, Toll-Like Receptors Cascades