SENP6 Antikörper (AA 811-1112)

Produktnummer ABIN7270635

Produktdetails anti-SENP6 Antikörper

Target: SENP6 (SUMO1/sentrin Specific Protease 6 (SENP6))

Bindungsspezifität: AA 811-1112

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SENP6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Verwendungszweck: SENP6 Rabbit pAb

Sequenz: MESCSQNSSA KPVIKKMLNK KHCIAVIDSN PGQEESDPRY KRNICSVKYS VKKINHTASE NEEFNKGEST SQKVADRTKS ENGLQNESLS STHHTDGLSK IRLNYSDESP EAGKMLEDEL VDFSEDQDNQ DDSSDDGFLA DDNCSSEIGQ WHLKPTICKQ PCILLMDSLR GPSRSNVVKI LREYLEVEWE VKKGSKRSFS KDVMKGSNPK VPQQNNFSDC GVYVLQYVES FFENPILSFE LPMNLANWFP PPRMRTKREE IRNIILKLQE DQSKEKRKHK DTYSTEAPLG EGTEQYVNSI SD

Kreuzreaktivität: Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 811-1112 of human SENP6 (NP_056386.2).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu SENP6

Target: SENP6 (SUMO1/sentrin Specific Protease 6 (SENP6))

Andere Bezeichnung: SENP6 (SENP6 Produkte)

Synonyme: SSP1 antikoerper, SUSP1 antikoerper, 2810017C20Rik antikoerper, E130319N12Rik antikoerper, Susp1 antikoerper, mKIAA0797 antikoerper, fc83h02 antikoerper, im:7148342 antikoerper, wu:fc83h02 antikoerper, zgc:171230 antikoerper, SUMO1/sentrin specific peptidase 6 antikoerper, SUMO/sentrin specific peptidase 6 antikoerper, SUMO1/sentrin specific peptidase 6a antikoerper, SENP6 antikoerper, Senp6 antikoerper, senp6a antikoerper

Hintergrund: Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1, MIM 601912), are structurally related to ubiquitin (MIM 191339) and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 (MIM 602362) to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha (NFKBIA, MIM 164008) from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins (Kim et al., 2000 [PubMed 10799485]). SENPs also display isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 [PubMed 18799455]).[supplied by OMIM, Jun 2009],SSP1,SUSP1,SENP6,Epigenetics & Nuclear Signaling,Cell Biology & Developmental Biology,Ubiquitin,SENP6

Gen-ID: 26054

UniProt: Q9GZR1