TNKS2 Antikörper (AA 780-1050)

Produktnummer ABIN7270726

Produktdetails anti-TNKS2 Antikörper

Target: TNKS2 (Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2 (TNKS2))

Bindungsspezifität: AA 780-1050

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TNKS2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Verwendungszweck: TNKS2 Rabbit pAb

Sequenz: TPLDLVSADD VSALLTAAMP PSALPSCYKP QVLNGVRSPG ATADALSSGP SSPSSLSAAS SLDNLSGSFS ELSSVVSSSG TEGASSLEKK EVPGVDFSIT QFVRNLGLEH LMDIFEREQI TLDVLVEMGH KELKEIGINA YGHRHKLIKG VERLISGQQG LNPYLTLNTS GSGTILIDLS PDDKEFQSVE EEMQSTVREH RDGGHAGGIF NRYNILKIQK VCNKKLWERY THRRKEVSEE NHNHANERML FHGSPFVNAI IHKGFDERHA Y

Kreuzreaktivität: Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 780-1050 of human TNKS2 (NP_079511.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu TNKS2

Target: TNKS2 (Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2 (TNKS2))

Andere Bezeichnung: TNKS2 (TNKS2 Produkte)

Synonyme: ARTD6 antikoerper, PARP-5b antikoerper, PARP-5c antikoerper, PARP5B antikoerper, PARP5C antikoerper, TANK2 antikoerper, TNKL antikoerper, pART6 antikoerper, 5430432P15Rik antikoerper, AA517131 antikoerper, AI662480 antikoerper, TNKS-2 antikoerper, Tank2 antikoerper, tankyrase-2 antikoerper, TNKS2 antikoerper, tankyrase-1 antikoerper, tnks antikoerper, tnks.L antikoerper, tnks2 antikoerper, tankyrase 2 antikoerper, tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 antikoerper, tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase S homeolog antikoerper, TNKS2 antikoerper, Tnks2 antikoerper, tnks2 antikoerper, tnks.S antikoerper

Hintergrund: Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. Stimulates 26S proteasome activity.,TNKS2,ARTD6,PARP-5b,PARP-5c,PARP5B,PARP5C,TANK2,TNKL,pART6,Epigenetics & Nuclear Signaling,Signal Transduction,Cell Biology & Developmental Biology,Cell Cycle,Centrosome,Wnt/β-Catenin Signaling Pathway,TNKS2

Molekulargewicht: 126kDa

Gen-ID: 80351

UniProt: Q9H2K2