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TMED2 Antikörper (AA 60-170)

TMED2 Reaktivität: Human WB, IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7270943
  • Target Alle TMED2 Antikörper anzeigen
    TMED2 (Transmembrane Emp24 Domain Trafficking Protein 2 (TMED2))
    Bindungsspezifität
    • 8
    • 7
    • 6
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 60-170
    Reaktivität
    • 37
    • 16
    • 12
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 37
    Kaninchen
    Klonalität
    • 37
    Polyklonal
    Konjugat
    • 16
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser TMED2 Antikörper ist unkonjugiert
    Applikation
    • 25
    • 20
    • 18
    • 4
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Verwendungszweck
    TMED2 Rabbit pAb
    Sequenz
    EITGPDNKGI YKGDRESSGK YTFAAHMDGT YKFCFSNRMS TMTPKIVMFT IDIGEAPKGQ DMETEAHQNK LEEMINELAV AMTAVKHEQE YMEVRERIHR AINDNTNSRV V
    Kreuzreaktivität
    Human, Maus, Ratte
    Produktmerkmale
    Polyclonal Antibodies
    Aufreinigung
    Affinity purification
    Immunogen
    Recombinant fusion protein containing a sequence corresponding to amino acids 60-170 of human TMED2 (NP_006806.1).
    Isotyp
    IgG
    Top Product
    Discover our top product TMED2 Primärantikörper
  • Applikationshinweise
    WB,1:500 - 1:2000,IF,1:50 - 1:200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    TMED2 (Transmembrane Emp24 Domain Trafficking Protein 2 (TMED2))
    Andere Bezeichnung
    TMED2 (TMED2 Produkte)
    Synonyme
    P24A antikoerper, RNP24 antikoerper, p24 antikoerper, 1110032D12Rik antikoerper, 1810020N21Rik antikoerper, Rnp24 antikoerper, Sid394 antikoerper, p24beta1 antikoerper, Chop24 antikoerper, transmembrane p24 trafficking protein 2 antikoerper, TMED2 antikoerper, Tmed2 antikoerper
    Hintergrund
    Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway but also in post-Golgi membranes. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED10 as their cargo receptor, the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1. In COPI vesicle-mediated retrograde transport inhibits the GTPase-activating activity of ARFGAP1 towards ARF1 thus preventing immature uncoating and allowing cargo selection to take place. Involved in trafficking of G protein-coupled receptors (GPCRs. Regulates F2RL1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Facilitates CASR maturation and stabilization in the early secretory pathway and increases CASR plasma membrane targeting. Proposed to be involved in organization of intracellular membranes such as the maintenance of the Golgi apparatus. May also play a role in the biosynthesis of secreted cargo such as eventual processing.,P24A,RNP24,p24,p24b1,p24beta1,TMED2,Signal Transduction,Cell Biology & Developmental Biology,TMED2
    Molekulargewicht
    22kDa
    Gen-ID
    10959
    UniProt
    Q15363
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