Tppp Antikörper

Produktnummer ABIN7271031

Produktdetails anti-Tppp Antikörper

Target: Tppp (Tubulin Polymerization Promoting Protein (Tppp))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser Tppp Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Verwendungszweck: TPPP/p25 Rabbit mAb

Kreuzreaktivität: Maus, Ratte

Produktmerkmale: Monoclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: A synthesized peptide derived from human TPPP/p25

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu Tppp

Target: Tppp (Tubulin Polymerization Promoting Protein (Tppp))

Andere Bezeichnung: TPPP (Tppp Produkte)

Synonyme: TPPP/p25 antikoerper, TPPP1 antikoerper, p24 antikoerper, p25 antikoerper, p25alpha antikoerper, 2900041A09Rik antikoerper, AI849835 antikoerper, RGD1310121 antikoerper, tubulin polymerization promoting protein antikoerper, TPPP antikoerper, Tppp antikoerper

Hintergrund: Regulator of microtubule dynamics that plays a key role in myelination by promoting elongation of the myelin sheath. Acts as a microtubule nucleation factor in oligodendrocytes: specifically localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, and promotes microtubule nucleation, an important step for elongation of the myelin sheath. Required for both uniform polarized growth of distal microtubules as well as directing the branching of proximal processes. Shows magnesium-dependent GTPase activity, the role of the GTPase activity is unclear. In addition to microtubule nucleation activity, also involved in microtubule bundling and stabilization of existing microtubules, thereby maintaining the integrity of the microtubule network. Regulates microtubule dynamics by promoting tubulin acetylation: acts by inhibiting the tubulin deacetylase activity of HDAC6. Also regulates cell migration: phosphorylation by ROCK1 inhibits interaction with HDAC6, resulting in decreased acetylation of tubulin and increased cell motility. Plays a role in cell proliferation by regulating the G1/S-phase transition. Involved in astral microtubule organization and mitotic spindle orientation during early stage of mitosis, this process is regulated by phosphorylation by LIMK2.,TPPP/p25, TPPP1, p24, p25, p25alpha,Cell Biology & Developmental Biology,Cytoskeleton,Cytoskeleton_Microtubules,Signal Transduction,TPPP

Molekulargewicht: 25kDa

Gen-ID: 11076

UniProt: O94811