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TXK Antikörper (AA 1-180)

TXK Reaktivität: Human WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7271114
  • Target Alle TXK Antikörper anzeigen
    TXK (TXK tyrosine Kinase (TXK))
    Bindungsspezifität
    • 7
    • 6
    • 3
    • 2
    • 1
    • 1
    AA 1-180
    Reaktivität
    • 25
    • 2
    • 2
    Human
    Wirt
    • 23
    • 3
    • 1
    Kaninchen
    Klonalität
    • 24
    • 3
    Polyklonal
    Konjugat
    • 12
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser TXK Antikörper ist unkonjugiert
    Applikation
    • 16
    • 15
    • 11
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Verwendungszweck
    TXK Rabbit pAb
    Sequenz
    MILSSYNTIQ SVFCCCCCCS VQKRQMRTQI SLSTDEELPE KYTQRRRPWL SQLSNKKQSN TGRVQPSKRK PLPPLPPSEV AEEKIQVKAL YDFLPREPCN LALRRAEEYL ILEKYNPHWW KARDRLGNEG LIPSNYVTEN KITNLEIYEW YHRNITRNQA EHLLRQESKE GAFIVRDSRH
    Kreuzreaktivität
    Ratte
    Produktmerkmale
    Polyclonal Antibodies
    Aufreinigung
    Affinity purification
    Immunogen
    Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human TXK (NP_003319.2).
    Isotyp
    IgG
    Top Product
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  • Applikationshinweise
    WB,1:500 - 1:2000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    TXK (TXK tyrosine Kinase (TXK))
    Andere Bezeichnung
    TXK (TXK Produkte)
    Synonyme
    BTKL antikoerper, PSCTK5 antikoerper, PTK4 antikoerper, RLK antikoerper, TKL antikoerper, A130089B16Rik antikoerper, Btkl antikoerper, Rlk antikoerper, TXK tyrosine kinase antikoerper, tyrosine-protein kinase TXK antikoerper, TXK antikoerper, Txk antikoerper, LOC100544958 antikoerper
    Hintergrund
    Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC activate T-cell receptor (TCR, a series of phosphorylation leads to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation. Contributes also to signaling from many receptors and participates in multiple downstream pathways, including regulation of the actin cytoskeleton. Like ITK, can phosphorylate PLCG1, leading to its localization in lipid rafts and activation, followed by subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT translocates into the nucleus to perform its transcriptional duty. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with PARP1 and EEF1A1. Within the complex, phosphorylates both PARP1 and EEF1A1. Phosphorylates also key sites in LCP2 leading to the up-regulation of Th1 preferred cytokine IL-2. Phosphorylates 'Tyr-201' of CTLA4 which leads to the association of PI-3 kinase with the CTLA4 receptor.,TXK,BTKL,PSCTK5,PTK4,RLK,TKL,Epigenetics & Nuclear Signaling,Signal Transduction,Kinase,Tyrosine kinases,Immunology & Inflammation,Cytokines,Interferons,Cell Intrinsic Innate Immunity Signaling Pathway,TXK
    Molekulargewicht
    61kDa
    Gen-ID
    7294
    UniProt
    P42681
    Pathways
    Regulation of Leukocyte Mediated Immunity, Hepatitis C
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