UPF3B Antikörper (AA 1-180)

Produktnummer ABIN7271228

Produktdetails anti-UPF3B Antikörper

Target: UPF3B (UPF3 Regulator of Nonsense Transcripts Homolog B (UPF3B))

Bindungsspezifität: AA 1-180

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser UPF3B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Verwendungszweck: UPF3B Rabbit pAb

Sequenz: MKEEKEHRPK EKRVTLLTPA GATGSGGGTS GDSSKGEDKQ DRNKEKKEAL SKVVIRRLPP TLTKEQLQEH LQPMPEHDYF EFFSNDTSLY PHMYARAYIN FKNQEDIILF RDRFDGYVFL DNKGQEYPAI VEFAPFQKAA KKKTKKRDTK VGTIDDDPEY RKFLESYATD NEKMTSTPET

Kreuzreaktivität: Maus

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human UPF3B (NP_075386.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu UPF3B

Target: UPF3B (UPF3 Regulator of Nonsense Transcripts Homolog B (UPF3B))

Andere Bezeichnung: UPF3B (UPF3B Produkte)

Synonyme: HUPF3B antikoerper, MRXS14 antikoerper, RENT3B antikoerper, UPF3X antikoerper, 5730594O13Rik antikoerper, AI317193 antikoerper, AW541158 antikoerper, RGD1560264 antikoerper, UPF3B, regulator of nonsense mediated mRNA decay antikoerper, UPF3 regulator of nonsense transcripts homolog B (yeast) antikoerper, UPF3B antikoerper, Upf3b antikoerper

Hintergrund: This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome X. Two splice variants encoding different isoforms have been found for this gene.,UPF3B,HUPF3B,MRX62,MRXS14,RENT3B,UPF3BP1,UPF3BP2,UPF3BP3,UPF3X,Upf3p-X,Epigenetics & Nuclear Signaling,RNA Binding,UPF3B

Molekulargewicht: 56kDa/57kDa

Gen-ID: 65109

UniProt: Q9BZI7