OSBP2 Antikörper (AA 221-320) (Biotin)

Produktnummer ABIN718078

Produktdetails anti-OSBP2 Antikörper (Biotin)

Target: OSBP2 (Oxysterol Binding Protein 2 (OSBP2))

Bindungsspezifität: AA 221-320

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser OSBP2 Antikörper ist konjugiert mit Biotin

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Human

Homologie: Mouse,Rat,Dog,Cow,Pig,Horse,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human OSBP2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu OSBP2

Target: OSBP2 (Oxysterol Binding Protein 2 (OSBP2))

Andere Bezeichnung: OSBP2 (OSBP2 Produkte)

Synonyme: ORP-4 antikoerper, ORP4 antikoerper, OSBPL1 antikoerper, OSBPL4 antikoerper, 1700095P05Rik antikoerper, C630001G20Rik antikoerper, Gm244 antikoerper, RGD1309479 antikoerper, oxysterol binding protein 2 antikoerper, OSBP2 antikoerper, Osbp2 antikoerper

Hintergrund:

Synonyms: ORP 4, ORP4, OSBLP4, OSBP-related protein 4, OSBP2, OSBPL1, OSBPL4, Oxysterol Binding Protein 2, Oxysterol Binding Protein-like 1, oxysterol binding protein-related protein 4, OSBP2_HUMAN.

Background: The Oxysterol-binding protein (OSBP) family of proteins consist of OSBP (OSBP1) and OSBP2 (ORP-4), which share a high overall similarity. OSBPs are involved in lipid metabolism and signal transduction, as well as vesicle transport, and can translocate to the periphery of Golgi membranes when they are bound to oxysterols. The OSBP protein transports sterols from lysosomes to the nucleus, where sterols downregulate the genes for HMG synthetase, HMG-CoA reductase and the low density lipoprotein receptor (LDLR). OSBP localizes to the cytosol and is widely expressed, while OSBP2 is mainly detected in testis, retina and fetal liver. The extracellular signal-regulated kinase (ERK) signaling pathway is controlled by OSBP via its cholesterol-binding properties. OSBP binds with a high affinity to 25-hydroxy-cholesterol (25-HC), a suppressor of cholesterol synthesis gene transcription in cultured cells.

Gen-ID: 23762